Results 71 to 80 of about 1,924,515 (315)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
EcosphereBirds and their habitats are threatened with extinction around the world. Regional assessments of the “State of Birds” are a vital means to prioritize data‐driven conservation action by informing national and global policy.
Ashwin Viswanathan +15 more
doaj +1 more source
Health Research Policy and Systems, 2017 Background Chronic diseases are a serious and urgent problem, requiring at-scale, multi-component, multi-stakeholder action and cooperation. Despite numerous national frameworks and agenda-setting documents to coordinate prevention efforts, Australia ...
Sonia Wutzke +5 more
doaj +1 more source
A Community Benefit Agreement for the Buffalo Niagara Medical Campus [PDF]
, 2016 The BNMC is the region’s largest economic development project. Clustering health institutions together on one campus creates many collaborations and efficiencies and increases the potential for spin-off job creation.
Partnership for the Public Good
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Raising the Minimum Wage: Key Facts and Figures [PDF]
, 2014 In New York State, roughly 37% or workers earn low wages (less than $15 per hour, or $31,200 per year). In Erie County, the percentage is 41% (159,800 of 393,600 wage-earning workers). 94% of low wage workers in New York State are age 20 or over.
Partnership for the Public Good
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Greening the Buffalo Niagara Medical Campus [PDF]
, 2015 The Medical Campus is dedicated to improving health, and a sustainable campus will improve the health of the patients, visitors, workers, and neighbors of the campus, as well as that of the general public. Sustainability measures such as improving energy
Partnership for the Public Good
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
East Midlands urban action plan 2005-2011 [PDF]
, 2005 This is the second urban action plan (UAP) for the East Midlands. The plan sets out a framework for urban renaissance in the East Midlands and provides a delivery plan that includes significant schemes in the priority urban areas that will influence the ...
Urban Partnership Group
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