Results 131 to 140 of about 1,543,646 (293)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ginsenoside CK and retinol on UVA-induced photoaging exert the synergistic effect through antioxidant and antiapoptotic mechanisms

Scientific Reports
Retinol and retinoids can effectively intervene skin aging process, but usually induce skin intolerance. In this study, we aimed to determine the synergistic anti-aging effects of retinol and two retinol derivatives-hydroxypinacolone retinoate (HPR) and ...
Jingyin Zhang, Zhuojun Li, Xiaoping Song, Panpan Cai, Qingchao Liu   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Research institute partnerships 2015 [PDF]

Bioentrepreneur, 2016
openaire   +2 more sources

Academic-Community Partnerships: Effectiveness Evaluated Beyond the Ivory Walls [PDF]

, 2019
Community-based participatory research (CBPR) has furthered our understanding of the working principles required for academic-community partnerships to address persistent public health problems.
Caron, Rosemary M., Lafferty, Catherine, Ulrich-Schad, Jessica D.   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Understanding implementation of findings from trial method research: a mixed methods study applying implementation frameworks and behaviour change models

Trials
Background Trial method research produces recommendations on how to best conduct trials. However, findings are not routinely implemented into practice.
Taylor Coffey, Paula R. Williamson, Katie Gillies, on behalf of the Trials Methodology Research Partnership Working Groups   +3 more
doaj   +1 more source

From Disruption to Reconstruction: Implementing Peer Support in Homelessness During Times of Crisis for Health and Social Care Services

International Journal of Integrated Care
Introduction: Peer support workers—people with a significant lived and living experience of a social or health condition—use their experiential knowledge and obtain training to help and care for others. They are integrated in different clinical settings,
Mathieu Isabel, Daniel Turgeon, Émilie Lessard, Andreea-Cătălina Panaite, Gwenvaël Ballu, Odile-Anne Desroches, Ghislaine Rouly, Antoine Boivin   +7 more
doaj   +1 more source

Building public–private partnerships for agricultural innovation in Latin America: Lessons from capacity strengthening [PDF]

"The International Service for National Agricultural Research on its own from 2002 until 2003, and as a division of the International Food Policy Research Institute thereafter has studied 124 public–private partnerships in agriculture in nine Latin ...
Babu, Suresh Chandra, Gottret, Maria Veronica, Hartwich, Frank, Tola, Jaime   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source