Results 61 to 70 of about 416,239 (311)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Understanding Co‐Creation in a Research Partnership Programme Exploring Patient‐Driven Innovations: A Qualitative Longitudinal Study

Health Expectations
Background Research indicates that successful co‐creation depends on a shared understanding of co‐creation and its related concepts. However, it also shows that, in practice, views on co‐creation and how to do it differ.
Hanna Jansson, Jamie L. Luckhaus, Henna Hasson, Pamela Mazzocato, Terese Stenfors, Carolina Wannheden   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

European and Developing Countries Clinical Trials Partnership (EDCTP): The Path Towards a True Partnership. [PDF]

, 2009
European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, and Developing Countries, formed to fund ...
Jaoko, W.G., Lynn Zijenah, Ndounga, M., Ndounga, Mathieu, Zijenah, L., Adjei, D.O., Agwale Simon, Manyando, Christine, Nyirenda Thomas, Ambene, H.P.A., Manyando, C., Walter G Jaoko, Zijenah Lynn, Ndounga Mathieu, Shongwe Steven, Jaoko, Walter G, Nyirenda, T., Herman PA Ambene, Manyando Christine, Jaoko Walter G, Shongwe, S., Michael Makanga, Tumani Corrah, Corrah, Tumani, Matee Mecky I, Corrah Tumani, Zijenah, Lynn, Agwale, S., Simon Agwale, Agwale, Simon, Corrah, T., Christine Manyando, David Ofori-Adjei, Kitua, A.Y., Peter M Ndumbe, Shongwe, Steven, Mecky I Matee, Ambene, Herman Pa, Makanga, Michael, Makanga, M., Ndumbe Peter M, Matee, Mecky I, Ndumbe, Peter M, Matee, M.I., Ambene Herman PA, Nyirenda, Thomas, Kitua, Andrew Y, Ofori-Adjei, David, Steven Shongwe, Andrew Y Kitua, Ndumbe, P.M., Ofori-Adjei David, Makanga Michael, Kitua Andrew Y, Thomas Nyirenda, Mathieu Ndounga   +55 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana

Viruses, 2020
Hepatitis B virus (HBV) is the primary cause of liver-related malignancies worldwide, and there is no effective cure for chronic HBV infection (CHB) currently.
Wonderful Tatenda Choga, Motswedi Anderson, Edward Zumbika, Bonolo B. Phinius, Tshepiso Mbangiwa, Lynnette N. Bhebhe, Kabo Baruti, Peter Opiyo Kimathi, Kaelo K. Seatla, Rosemary M. Musonda, Trevor Graham Bell, Sikhulile Moyo, Jason T. Blackard, Simani Gaseitsiwe   +13 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Cross-CRP Analysis of Partnership Strategies in the 2017-2022 CRP2 [PDF]

, 2023
This brief provides a summary analysis of how well the CGIAR Research Programs (CRPs) are planning the design and implementation of their partnership strategies, and how the strategic partnership activities contribute to the outputs and outcomes of the ...
CGIAR Independent Science and Partnership Council
core  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source