Results 71 to 80 of about 416,239 (311)

Building bridges: enhancing cultural understanding and community engagement in the CHAMPS program—experience sought from Gobe Challa Village, Ethiopia

Discover Social Science and Health
Public health programs’ successful implementation often requires a thorough consideration ⁠ of local cultural contexts and effective community engagement.
Haleluya Leulseged, Faisel Abdi, Abdella Mohamed, Getahun Wakoya, Mohamed Aliyi, Adane Tesfaye, Segni Yali, Khalifa Mohamed, Akile Mohamed, Eden Yilma, Mulualem Saboka, Maji Bifle, Serkalem, Obsitu Hussein, Freedom Aklilu, Hawi Eshetu, Mestu Tafa, Obsa Ahmed, Mohamed Abdo, Lola Madrid, Nega Assefa   +20 more
doaj   +1 more source

An International Cross-cohort Harmonization and Data Integration Initiative towards Achieving Statistical Power and Meaningful Results

International Journal of Population Data Science, 2017
Objectives The complex interaction between lifestyle, behaviours, genetic factors and the social and physical environment have a fundamental role in modulating risk and/ or progression of health outcomes, especially cancer.
Tanya Flanagan, Isabel Fortier, Mélanie Fon Sing, Celine Moore   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Corporate responsibility, supply chain partnership and performance: An empirical examination

, 2012
This is the post-print version of the final paper published in International Journal of Production Economics. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections,
Ghobadian, A, Ghobadian, A., Gallear, D, Chen, Weifeng, Gallear, David, Chen, W., Weifeng Chen, David Gallear, Abby Ghobadian, Chen, W, Ghobadian, Abby, Gallear, D.   +11 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Reflections on student-staff research partnership: Opportunities, benefits, & challenges [PDF]

This paper explores the opportunities for student-staff partnership in the research process, before progressing to examine the benefits and challenges of such engagement. Using the model of Healey (2005), opportunities for student partnership in research
Hill, Jennifer, West, Harry
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Municipal Development Partnership (MDP) : Eastern and Southern Africa ; annual report 2002; a partnership enabling local government capacity

, 2003
The programme is designed to be an alternative model of development assistance, operating regionally, nationally, and locally and dedicated to building local institutional effectiveness in Sub-Saharan Africa.
Municipal Development Partnership
core  

Deepening democracy within Ireland's social partnership [PDF]

, 2009
Ireland's social partnership process, now under attack from a number of quarters, has repeatedly been charged with being 'undemocratic' in that it undermines the sovereign position of elected political representatives, with key policy formulation and ...
Gaynor, Niamh, Niamh Gaynor
core   +1 more source