Results 171 to 180 of about 133,619 (388)

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

Asymmetric Inter‐Hemisphere Communication Contributes to Speech Acquisition of Toddlers with Cochlear Implants

open access: yesAdvanced Science, EarlyView.
The present study constructs machine‐learning models to resolve developmental relationships among auditory performance, auditory cortical processing, and functional connectivity of the bilateral language network during the first year of restored hearing. The results demonstrate that asymmetric inter‐hemisphere communication contributes significantly to
Xue Zhao   +6 more
wiley   +1 more source

Using animal-mounted sensor technology and machine learning to predict time-to-calving in beef and dairy cows

open access: yesAnimal, 2020
Worldwide, there is a trend towards increased herd sizes, and the animal-to-stockman ratio is increasing within the beef and dairy sectors; thus, the time available to monitoring individual animals is reducing. The behaviour of cows is known to change in
G.A. Miller   +10 more
doaj  

D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
Downregulating D‐2‐hydroxyglutarate dehydrogenase (D2HGDH) increases epilepsy susceptibility by altering reactive oxygen species (ROS) levels and synaptic function, contributing to oxidative stress in neurons. The acid calcium‐independent phospholipase A2 (aiPLA2) inhibitor MJ33 restores glutathione reduced/glutathione oxidized balance, reducing ROS ...
Zhijuan Zhang   +14 more
wiley   +1 more source

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo   +17 more
wiley   +1 more source

3D Printed Mesh Geometry Modulates Immune Response and Interface Biology in Mouse and Sheep Model: Implications for Pelvic Floor Surgery

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
Pelvic organ prolapse (POP) is a significant health challenge for women, especially with the lack of optimal surgical options post‐withdrawal of synthetic transvaginal meshes. The study pioneers degradable melt electrowrite vaginal implants with precise 22.5° angles and specific porosity. These configurations significantly influence macrophage behavior
Kallyanashis Paul   +7 more
wiley   +1 more source

Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics [PDF]

open access: yes, 2016
Bennett, PR   +9 more
core   +1 more source

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