Results 211 to 220 of about 133,619 (388)

Applications of Artificial Intelligence in Drug Repurposing

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Artificial intelligence algorithms are transforming drug repurposing by revealing new therapeutic targets and mechanisms. This review highlights the integration of AI frameworks, multimodal datasets, and advanced optimization methods, accelerating the discovery of new indications for existing drugs.
Zhaoman Wan, Xinran Sun, Yi Li, Tianyao Chu, Xueyu Hao, Yang Cao, Peng Zhang   +6 more
wiley   +1 more source

The Chemistry of the Blood of Dairy Cows before and after Parturition and Its Relation to Milk Fever

, 1932
Logan T. Wilson, E.B. Hart
openalex   +1 more source

THE INJURIES OF PARTURITION, THE TIME, METHOD AND REASONS FOR THEIR REPAIR. [PDF]

, 1897
ALBERT H. TUTTLE
openalex   +1 more source

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science, EarlyView.
By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
wiley   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

A Pilot Study To Evaluate The Effect Of A Novel Calcium And Vitamin D-Containing Oral Bolus On Serum Calcium Levels In Holstein Dairy Cows Following Parturition

Veterinary Medicine: Research and Reports, 2019
Daniel A Shock,1 Steven M Roche,1 Rachel Genore,1,2 Merle E Olson3 1Agricultural Communications and Epidemiological Research (ACER) Consulting, Guelph, Ontario, Canada; 2Heartland Veterinary Services, Listowel, Ontario, Canada; 3Solvet Animal Health ...
Shock DA, Roche SM, Genore R, Olson ME
doaj  

A Comparison of Some Cellular and Chemical Constituents of Blood at Time of Parturition and after Administration of Adrenocorticotrophin

, 1954
Wyatt G. Merrill, Vearl R. Smith
openalex   +1 more source

Ovarian Cyst Suppurating after Parturition: Hyperpyrexia: Ovariotomy: Recovery [PDF]

, 1882
W. H. Day
openalex   +1 more source

Parturition and the perinatal period: can mode of delivery impact on the future health of the neonate?

Journal of Physiology, 2018
R. Tribe, Paul D. Taylor, Niamh M Kelly, David C. Rees, Jane Sandall, H. P. Kennedy   +5 more
semanticscholar   +1 more source

Cardiomyocyte Foxp1‐Specific Deletion Promotes Post‐injury Heart Regeneration via Targeting Usp20‐HIF1ɑ‐Hand1 Signaling Pathway

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study shows that Foxp1 regulates the USP20–HIF1ɑ‐Hand1 pathway, controlling cardiomyocyte metabolic reprogramming, proliferation, and heart regeneration. By targeting Hand1, the downstream effector, this work suggests a promising molecular target for gene therapy of heart failure, potentially guiding the development of novel molecular ...
Yanfang Wang, Xiaoyu Wang, Ji Fang, Xiaoli Chen, Teng Xu, Tao Zhuang, Sheng Peng, Wenzhen Bao, Wenrun Wu, Yushi Lu, Haikun Wang, Brian Tomlinson, Paul Chan, Shougang Zhuang, Qi Zhang, Lin Zhang, Zhongmin Liu, Jingjiang Pi, Yuzhen Zhang, Jie Liu   +19 more
wiley   +1 more source