Results 141 to 150 of about 65,754 (264)

Variation in Stabilization and Resuscitation Practices at Birth of Preterm Infants Among 12 National or Regional Neonatal Networks

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Neonatal resuscitation follows national or regional guidelines, but uptake varies in clinical practice. This study aimed to examine variations in reported delivery room practices for infants < 29 weeks' gestation across neonatal units in 12 networks of the International Network for Evaluating Outcomes in Neonates.
Maria Fernanda de Almeida   +676 more
wiley   +1 more source

Disciplining the “Queen of the World”? Responsible Innovation as a Way of Life

open access: yesBusiness Ethics, the Environment &Responsibility, EarlyView.
ABSTRACT This paper offers a critical reflection on the concept of responsible innovation as defined during the last decades. We argue that the emphasis on innovation as a process risks neglecting the very goals of innovation, namely societal desirability and acceptability. Thus, we suggest reconsidering the role of imagination, the “Queen of the world”
Xavier Pavie   +2 more
wiley   +1 more source

An overview of Mass Accumulation Rates in key Polish loess–palaeosol sequences derived from luminescence chronologies

open access: yesBoreas, EarlyView.
Loess–palaeosol sequences (LPS) represent one of the most important continental archives of late Quaternary environmental change in Europe. Establishing reliable chronologies is essential for reconstructing dust dynamics and for correlating regional loess stratigraphies. In this study, we present the first systematically derived mass accumulation rate (
Maksymilian Jędrzejowski   +7 more
wiley   +1 more source

Applying Design Science in Creativity and Innovation Management Research: A Decision Guide for Deepening Research Practice

open access: yesCreativity and Innovation Management, EarlyView.
ABSTRACT Creativity and innovation management research (CIMR) seeks to understand how creative and innovative solutions emerge. Recently, greater practitioner engagement, interdisciplinary integration, process orientation and context‐sensitive impact measurement have been proposed as realms of further development.
Anna Margolis   +3 more
wiley   +1 more source

Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth via STING‐Mediated Type I Interferon Response in iCCA

open access: yesCancer Science, EarlyView.
Through bioinformatic analyses, iCCA cell models, and in vivo xenograft experiments, we show that autophagy inhibition sensitizes iCCA to MEK1/2 blockade by enhancing STING‐dependent type I interferon signaling. These findings support combined MEK1/2 and autophagy inhibition as a promising therapeutic strategy for iCCA. ABSTRACT The RAF–MEK–ERK pathway
Chengqiang Sun   +15 more
wiley   +1 more source

Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Context Klinefelter syndrome (KS), defined by a 47, XXY karyotype, is commonly associated with progressive testicular failure. The precise timing of Sertoli and Leydig cell dysfunction during puberty remains unclear. Objective To determine the onset and progression of testicular insufficiency during puberty in KS, and to assess whether ...
Tredez Axelle   +9 more
wiley   +1 more source

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