Results 81 to 90 of about 319,384 (262)
A Note on Some Rates of Convergence in First-Passage Percolation
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
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Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
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Marking Food for Studying Its Rate of Passage in Poultry
Abstract A review of methods used to study the rate of food passage in poultry shows that no consistant technique for marking food has been adopted. Apparently no indicator possessing all the necessary requirements of a reliable marker has been found and described. An effective marker must have the following qualities. It must be convenient and easy
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Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
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Temporal Passage and the 'no alternate possibilities' argument
Dynamic theories of time typically commit to the claim that "time passes". In this paper I develop a version of the 'no alternate possibilities' argument in order to show that time does not pass, but that this is no threat to dynamic theories of time.
Jonathan Tallant
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Diet and the Rate of Food Passage in the Growing Chick
ABSTRACT THE rate at which feed passes through the digestive tract of the chick may influence the nutrition of the chick by (1) determining the length of time during which nutrients may be absorbed, (2) determining the microbial population of the intestine and (3) limiting the daily feed intake.
Ralph Tuckey, B.E. March, J. Biely
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Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
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