Results 91 to 100 of about 319,384 (262)
BMC Cell Biology, 2006 Background The present study was carried out to determine whether the p53 pathway played a role in the spontaneous immortalization of the SC-2 chicken embryo fibroblast (CEF) cell line that has been in continuous culture for over three years. Results The
Kim Hyunggee +4 more
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The Rate of the Passage of Time in Inertial Coordinate Systems
Journal of Advance Research in Mathematics And Statistics (ISSN 2208-2409)A comparison of the rate of the passage of time was made based on the results of the Michelson-Morley experiment in inertial <span>coordinate systems, stationary (x,y,z,t) and moving (x',y',z',t').lt was found that the time flows at the same speed in a moving and stationary syste ms.</span> <br>
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Time dilation and rates of the passage of time
THEORIA. An International Journal for Theory, History and Foundations of ScienceDebate over the issue of the rate of the passage of time has been persisting in the academic literature for decades without substantial progress. The common explanations of the (empirically well-confirmed) time dilation effects from Special and General Relativity theories requires that there is a physical passage of time which occurs at varying rates ...
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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How to Avoid the Problem of the Question of the Rate of Time’s Passage
Revista Portuguesa de Filosofia, 2015 The paper analyzes some recent versions of the objection to the existence of the flow of time based on the question: “How fast does time flow?”. It shows that the replies given to the problem are implausible and instead proposes a solution for the issue in the form of a conception of the flow of time which can avoid such a difficulty.
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Numerical study and experimental validation of a Roots blower with backflow design
Engineering Applications of Computational Fluid Mechanics, 2018 A three-dimensional computational fluid dynamics (CFD) model of a Roots blower with a backflow design was established to analyse the effects of the backflow on the Roots blower's performance.
Shu-Kai Sun +3 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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