Results 121 to 130 of about 1,240,534 (281)
A Patent Reformist Supreme Court and Its Unearthed Precedent [PDF]
, 2019 How is it that the Supreme Court, a generalist court, is leading a project of innovation reform in our times while the court of appeals established to encourage innovation is having its precedent stricken down time and again?
Ernst, Samuel F
core +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Managing at the Speed of Light: Improving Mission-Support Performance [PDF]
, 2009 The House and Senate Energy and Water Development Appropriations Subcommittees requested this study to help DOE's three major mission-support organizations improve their operations to better meet the current and future needs of the department.
Allan Burman +7 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
El acto según Mishima: entre la escritura y el cuerpo
Desde el Jardín de Freud, 2009 Resumen Tres elementos articulan la vida y la obra del escritor japonés Yukio Mishima: la escritura, el cuerpo y la acción. Tomando como base su ensayo El sol y el acero, propongo una reflexión acerca de estos tres temas.
María Lucía Correa
doaj +2 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
, 2007 The story of American democracy is often told as the steady expansion of voting but history has not yet caught up with one group -- former felons. In the early American political system, the right to vote was reserved for white males over the age of 21 ...
core
Publius: The Journal of Federalism, 2019 AbstractThe Tax Cuts and Jobs Act of 2017 (TCJA) was the first major federal tax reform in a generation. This article examines the priority issues of fifty-seven intergovernmental advocacy organizations during the legislation’s passage. These groups played defense from the start, in response to efforts by President Trump and congressional Republicans ...
openaire +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source