Results 121 to 130 of about 602,894 (237)

Intracellular mechanosensation in intestinal smooth muscle: Piezo1 complexes amplify signalling beyond the surface

The Journal of Physiology, EarlyView.
Abstract figure legend Mechanosensation is not confined to the cell surface. In intestinal smooth muscle Piezo1 is predominantly intracellular (86%), where it forms a nanoscale (<40 nm) complex at the sarcoplasmic reticulum (SR)–plasma membrane junction. Within this sensor–amplifier–effector axis intra‐Piezo1 is the sensor that detects force at the SR,
Geoanna M. Bautista, Declan Manning, Emily C. Lieu, Stephanie I. Ugochukwu, Collin Matsumoto, Joshua P. Tulman, Miguel Martin‐Aragon Baudel, Nuria Daghbouche‐Rubio, Steven J. McElroy, Sal A. Baker, Manuel F. Navedo, L. Fernando Santana   +11 more
wiley   +1 more source

Active and Passive Euthanasia: Current Opinion of Mexican Medical Students. [PDF]

Cureus, 2018
Gutierrez Castillo A, Gutierrez Castillo J.   +1 more
europepmc   +1 more source

Intrahousehold aggression in two dogs with pain experience as the primary motivational factor of the dogs’ aggressive behaviours

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract We present two cases of intrahousehold aggression in dogs experiencing undiagnosed physical discomfort, including pain. Pain was expected to be a motivational factor, as a physical issue marked the start of the aggression and as not all stimuli were related to the dogs’ direct external environment, pointing at possible internal stimuli. Victim‐
I. R. van Herwijnen, S. M. A. Gardeweg, C. M. Vinke, P. Schulte, D. Hartman   +4 more
wiley   +1 more source

Total duplication of the femur and polydactyly in the same limb of a Korean native calf

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract This case report describes a neonatal Korean native calf presenting with total duplication of the femur and polydactyly within the same hindlimb—an extremely rare congenital anomaly not previously reported in cattle. The calf exhibited marked structural deformities and inability to stand independently.
Geonil Moon, Suyoung Heo, Namsoo Kim
wiley   +1 more source

Spontaneous Hepatobiliary Disease in a Breeding Colony of Aotus spp.

Journal of Medical Primatology, Volume 55, Issue 5, October 2026.
ABSTRACT Background Owl monkeys are nonhuman primate species in the genus Aotus. The Michale E. Keeling Center for Comparative Medicine and Research maintains an Owl Monkey Breeding and Research Resource composed of four species of owl monkeys: Aotus nancymai, A. vociferans, A. azarae, and A. griseimembra.
M. E. Hensel, G. W. Wilkerson, L. Yan, C. L. Hodo, S. M. Kezar   +4 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, Volume 16, Issue 9, Page 1741-1751, September 2026.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Euthanasia - Choice and Death

, 2005
Euthanasia has become increasingly contentious as populations age, and medical and scientific advances continue to transform and extend life. Euthanasia - Choice and Death examines the key philosophical arguments that have underpinned thinking and ...
Tulloch, Gail
core  

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen, Boris Rivkin, David Castellanos‐Robles, Ivan Soldatov, Lukas Beyer, Mariana Medina‐Sánchez   +5 more
wiley   +1 more source

Should passive euthanasia be made legal in South Africa? [PDF]

, 2009
In In 1999 the South African Law Reform Commission proposed a draft bill on End of Life Decisions and tabled the Bill before Parliament. To date the Bill is still yet to be put up for discussion perhaps due to the sensitive nature of the subject.
Chidoori, Rumbidzai Elizabeth Portia
core  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source