Results 131 to 140 of about 38,122 (295)

Heart dysfunction in a rat model with autosomal recessive polycystic kidney disease

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Our results demonstrate a diastolic dysfunction in animals with severe kidney disease. Moreover, chronic kidney disease (CKD)‐induced heart fibrosis and hypertrophy are associated with a dysregulation of cardiokine signalling in autosomal recessive polycystic kidney disease (ARPKD) animals. Created using BioRender.com.
Nathalie Gayrard   +11 more
wiley   +1 more source

Attitudes of Registered Nurses in Designated South Dakota Hospitals Toward Aspects of Terminal Patient Care and Euthanasia [PDF]

open access: yes, 1972
The problem under investigation in this study is: What are the attitudes of professional nurses in designated hospitals in South Dakota toward the practice of passive and active euthanasia, and how do these attitudes vary when controlled for selected ...
Hofland, Sharon Ann
core   +1 more source

MTCH2 Suppresses Thermogenesis by Regulating Autophagy in Adipose Tissue

open access: yesAdvanced Science, Volume 12, Issue 17, May 8, 2025.
This study demonstrates that MTCH2 acts as an evolutionarily conserved regulator of energy homeostasis across Drosophila, rodents, and humans. Adipose‐specific MTCH2 ablation enhances brown/beige adipose thermogenesis through Bcl‐2‐dependent autophagy, promoting energy expenditure and counteracting obesity‐associated metabolic disorders. These findings
Xin‐Yuan Zhao   +17 more
wiley   +1 more source

Are Passive Spiral Galaxies truly 'passive' and 'spiral'?: a Near-Infrared perspective [PDF]

open access: yesarXiv, 2005
Passive spiral galaxies - unusual galaxies with spiral morphologies but without any sign of on-going star formation - have recently been shown to exist preferentially in cluster infalling regions. This discovery directly connects passive spiral galaxies to cluster galaxy evolution studies, such as the Butcher-Oemler effect or the morphology-density ...
arxiv  

Aquaporin 4 modulation drives amyloid burden and cognitive abilities in an APPPS1 mouse model of Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION Deficiency in the aquaporin‐4 (AQP4) water channel has been linked to impaired amyloid beta (Aβ) clearance. However, a detailed morphopathological analysis of amyloid deposition following AQP4 therapeutic modulation remains unexplored.
Marina Daniela Manescu   +10 more
wiley   +1 more source

Controversies Surrounding the Hopelessly Ill Patient [PDF]

open access: yes, 1975
Dr. Cassem, who acted as Guest Editor for this issue of the Linacre Quarterly, is Associate Professor of Psychiatry, Harvard Medical School, and is a member of the psychiatry staff at Massachusetts General Hospital.
Cassem, Ned H.
core   +1 more source

Role of STING Deficiency in Amelioration of Mouse Models of Lupus and Atherosclerosis

open access: yesArthritis &Rheumatology, Volume 77, Issue 5, Page 547-559, May 2025.
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune syndrome characterized by autoreactive responses to nucleic acids, dysregulation of the type I interferon (IFN‐I) pathway, and accelerated atherosclerosis. The stimulator of IFN genes (STING), a cytosolic DNA sensor, has pathogenic implications in various inflammatory diseases ...
Yudong Liu   +10 more
wiley   +1 more source

Localized Microrobotic Delivery of Enzyme‐Responsive Hydrogel‐Immobilized Therapeutics to Suppress Triple‐Negative Breast Cancer

open access: yesSmall, Volume 21, Issue 18, May 5, 2025.
In response to enzymatic activity within the tumor microenvironment, remotely actuated microrobots designed for localized delivery of stimuli‐responsive hydrogels engineered to release chemotherapeutics (ChemoBots) are developed. The system leverages magnetic navigation for targeted localization and prolongsed drug release, achieving marked tumor ...
Mingzhen Tian   +4 more
wiley   +1 more source

New experimental model of exposure to environmental tobacco smoke [PDF]

open access: yesActa Cirúrgica Brasileira, 2013
PURPOSE: To describe a new model to passive smoking for rodents. METHODS: Twenty rats were distributed into two study groups (N=10): control group (CG), that was not exposed to tobacco smoke and used as normal standard for biochemical and histological ...
Marcus Vinicius Henriques Brito   +6 more
doaj  

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