Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation
Angewandte Chemie, EarlyView.Heteroatom‐containing plastics such as polyurethanes and nylons are produced at scale yet remain largely unrecycled. Biocatalysts offer a promising route to depolymerization under mild conditions. Here, we present a screening platform for the discovery of novel polyurethane‐ and nylon‐degrading enzymes from environmental samples and demonstrate ...
Malthe Kjær Bendtsen +17 more
wiley +2 more sources
Harnessing Quantum Computing for Energy Materials: Opportunities and Challenges. [PDF]
ACS Energy LettKim S +5 more
europepmc +1 more source
Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System
Annals of Neurology, EarlyView.Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti +17 more
wiley +1 more source
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
Angewandte Chemie, EarlyView.We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne +5 more
wiley +2 more sources
Fuzzy adaptive fault-tolerant control for an unmanned surface vehicle with prescribed tracking performance. [PDF]
Front Robot AIBao Y, Gao J, Peng P.
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham +8 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Bowl‐shaped Janus nanomotors with platinum, iron oxide, and polypyrrole integrate catalytic, magnetic, and electric propulsion for targeted drug delivery. They demonstrate controlled, directional motion under varying pH and hydrogen peroxide conditions, with optimal performance in neutral media.
Kimia Tavakoli Dehaghi +3 more
wiley +1 more source
Intelligent Fault-Tolerant Control of Delta Robots: A Hybrid Optimization Approach for Enhanced Trajectory Tracking. [PDF]
Sensors (Basel)Domínguez C, Urrea C.
europepmc +1 more source
Digital Twin Approach for Fault Diagnosis in Photovoltaic Plant DC-DC Converters. [PDF]
Sensors (Basel)Hueros-Barrios PJ +6 more
europepmc +1 more source
An adaptive sliding mode fault-tolerant control of variable speed reaching law for steer-by-wire systems. [PDF]
Sci RepYang J +8 more
europepmc +1 more source