Results 41 to 50 of about 175,278 (262)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Passive Control Measures of Wind Flow around Tall Buildings

Buildings
The growth and diversification of tall buildings demands higher performance standards that encompass serviceability and resilience. In this respect, the control of air flow around tall buildings poses challenges to minimising the energy that could induce
Mario A. Aguirre-López, Filiberto Hueyotl-Zahuantitla, Pedro Martínez-Vázquez   +2 more
doaj   +1 more source

Effects of Active and Passive Control Techniques on Mach 1.5 Cavity Flow Dynamics

International Journal of Aerospace Engineering, 2017
Supersonic flow over cavities has been of interest since 1960s because cavities represent the bomb bays of aircraft. The flow is transient, turbulent, and complicated. Pressure fluctuations inside the cavity can impede successful weapon release.
Selin Aradag, Kubra Asena Gelisli, Elcin Ceren Yaldir   +2 more
doaj   +1 more source

Passive control of circular cylinder wake in shallow flow

Measurement, 2013
Abstract The control of vortex shedding of a circular cylinder in shallow water using a splitter plate located in the downstream of the circular cylinder was studied by employing particle image velocimetry (PIV) technique. Experiments were carried out in a water channel having a test section of 8000 mm × 1000 mm × 750 mm dimensions at a Reynolds ...
Gozmen, Bengi, Akilli, Huseyin, Sahin, Besir   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Experimental Aerodynamics of a Small Fixed-Wing Unmanned Aerial Vehicle Coated with Bio-Inspired Microfibers Under Static and Dynamic Stall

Aerospace
A passive flow control technique in the form of microfiber coatings with a diverging pillar cross-section area was applied to the wing suction surface of a small tailless unmanned aerial vehicle (UAV). The coatings are inspired from ‘gecko feet’ surfaces,
Dioser Santos, Guilherme D. Fernandes, Ali Doosttalab, Victor Maldonado   +3 more
doaj   +1 more source

Improving the Lift Characteristics of Supersonic Double 257 Wedge Airfoil at Low Speed Using Passive-Active Flow Controlling Methods [PDF]

Engineering and Technology Journal, 2015
The supersonic double wedge airfoil performs quite excellent in the supersonic speed regime but would lead to poor performance at subsonic speed regime due to sharp edges stall.
Mohammed I.Abutabikh, AbdulKareem Al-Musawi, Mohammed K. Khashan   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source