Results 21 to 30 of about 5,292,719 (305)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Passive Optical Access Networks: State of the Art and Future Evolution

Photonics, 2014
In the very last years, optical access networks are growing very rapidly, from both the network operators and the research interests points of view. Fiber To The Home (FTTH) is already a reality in plenty of real contexts and there has been a further ...
Tommaso Muciaccia, Fabio Gargano, Vittorio M. N. Passaro   +2 more
doaj   +1 more source

Reconfigurable remote nodes for hybrid passive optical networks [PDF]

, 2008
Mestrado em Engenharia Electrónica e TelecomunicaçõesO presente documento tem por objectivo demonstrar, analisar e optimizar nós remotos passivos para redes ópticas passivas baseadas numa topologia de anel de dupla fibra com multiplexagem no comprimento ...
Baptista, Albano Manuel Cardoso
core  

Performance optimization of free-space optical communication protocols based on results from FSO demonstrations [PDF]

, 2007
The mobile free-space optical channel mainly suffers from relatively long link outages, produced by short-term blockings of the line-of-sight (obstacles, clouds), pointing- and tracking-errors or deep signal-fades caused by index of refraction turbulence
Bernhard Epple, Epple, Bernhard
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Optical Power Budget Analysis of WDM-PON Traffic Protection Schemes

Photonics
To ensure high-quality and reliable service provision for customers, advanced optical networks without active elements have been developed to increase operating reliability, network scalability, and resource efficiency.
Filip Fuňák, Rastislav Róka
doaj   +1 more source

Remote Optical Monitoring in Remotely Power Assisted Passive Optical Networks

, 2010
In this paper, the authors present the latest results on a simple and low cost method to achieve a dynamic and flexible network monitoring. By placing several fiber Bragg gratings (FBG) along the passive optical gigabit Ethernet infrastructure (GePON ...
L. Costa, A. L. J. Teixeira, ANDO', Andrea, V. Carrozzo, Forin, DM, M. Tosi Beleffi, Tosi Beleffi, GM, D. M. Forin, Teixeira, ALJ, G. Incerti, Costa, L, BUSACCA, Alessandro, S. Pompei, Di Bartolo, S, Incerti, G, S. Di Bartolo, A. Busacca, Valenti, A, Pompei, S., A. Valenti, A. Ando, Carrozzo, V   +21 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Lossless WDM PON Photonic Integrated Receivers Including SOAs

Applied Sciences, 2019
The role of a semiconductor optical amplifier (SOA) for amplifying downstream traffic at optical network terminals (ONT) within a silicon-photonics integrated receiver in a high capacity passive optical network (PON) is investigated. The nearly traveling
Pantea Nadimi Goki, Muhammad Imran, Claudio Porzi, Veronica Toccafondo, Francesco Fresi, Fabio Cavaliere, Luca Potì   +6 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source