Results 1 to 10 of about 532 (108)

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons. [PDF]

Clin Transl Sci
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Srimatimanon T, Udomnilobol U, Chariyavilaskul P, Siwamogsatham S, Praditpornsilpa K, Vorasettakarnkij Y, Petchlorlian A, Vanwong N, Piriyapongsa J, Tipsombatboon P, Yodsurang V, Prueksaritanont T.   +11 more
europepmc   +2 more sources

Antiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma. [PDF]

Cancer Sci
Role of PON2 in regulating diverse molecular pathways influenced by PON2 during cancer progression and metastasis. Abstract Locally advanced oral squamous cell carcinoma poses a significant challenge in oncology due to its rising incidence and mortality rates. Despite therapeutic progress, understanding molecular intricacies is essential.
Kamal MV, Damerla RR, Parida P, Chakrabarty S, Rao M, Kumar NA.   +5 more
europepmc   +2 more sources

Dynamic bandwidth allocation in time division multiplexed passive optical networks: a dual-standard analysis of ITU-T and IEEE standard algorithms [PDF]

PeerJ Computer Science
In the last 25 years, operators have effectively established passive optical networks (PONs), catering to around 1 billion users and earning income surpassing 8.5 billion Euros. Major standardization bodies like IEEE and ITU-T have introduced several PON
Kamran Ali Memon, Syed Saeed Jaffer, Muhammad Ali Qureshi, Khurram Karim Qureshi   +3 more
doaj   +3 more sources

Performance study of a coexistence system in a PON network taking into account the stimulated scattering of Raman [PDF]

E3S Web of Conferences, 2022
Some problems introduced by the need for coexistence between a Passive Optical Network PON technologies (GPON, XGS-PON, and NG-PON2 in particular) especially the Stimulated Raman Scattering SRS which appears when different PON technologies transfer ...
Kherici Cheikh, Kandouci Malika
doaj   +1 more source

Optimization of the Decision Criterion for Increasing the Bandwidth Utilization by Means of the Novel Effective DBA Algorithm in NG-PON2 Networks

Future Internet, 2023
In this paper, the reasons for the bandwidth and wavelength utilization in future next-generation passive optical networks are presented, and the possibilities for realization and utilization of extended dynamic wavelength and bandwidth algorithms for ...
Rastislav Róka
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

MicroRNA signature and integrative omics analyses define prognostic clusters and key pathways driving prognosis in patients with neuroendocrine neoplasms

Molecular Oncology, Volume 17, Issue 4, Page 582-597, April 2023., 2023
The comprehensive characterisation of microRNA (miRNA) profiles of neuroendocrine neoplasms has identified an eight‐miRNA signature able to stratify patients into three prognostic groups. Transcriptomic data have shown that these miRNAs are associated with genes involved in PI3K–Akt and TNFα–NF‐kB signalling.
Beatriz Soldevilla, Alberto Lens‐Pardo, Paula Espinosa‐Olarte, Carlos Carretero‐Puche, Sonia Molina‐Pinelo, Carlos Robles, Marta Benavent, Lourdes Gomez‐Izquierdo, Marta Fierro‐Fernández, Patricia Morales‐Burgo, Paula Jimenez‐Fonseca, Beatriz Anton‐Pascual, Yolanda Rodriguez‐Gil, Ana Teijo‐Quintans, Anna La Salvia, Beatriz Rubio‐Cuesta, Maria C. Riesco‐Martínez, Rocio Garcia‐Carbonero   +17 more
wiley   +1 more source

Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages

Journal of Extracellular Vesicles, Volume 11, Issue 12, December 2022., 2022
Abstract Macrophages are important antigen presenting cells which can release extracellular vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be broadly classified into M1 ‘classical’ and M2 ‘alternatively‐activated’ macrophages. M1 macrophages have been linked with inflammation‐associated pathologies, whereas a switch
Paschalia Pantazi, Toby Clements, Morten Venø, Vikki M. Abrahams, Beth Holder   +4 more
wiley   +1 more source

Upgrading a Consumer Stereolithographic 3D Printer to Produce a Physiologically Relevant Model with Human Liver Cancer Organoids

Advanced Materials Technologies, Volume 7, Issue 10, October 10, 2022., 2022
This work shows that an affordable consumer stereolithography apparatus (SLA) printer can be straightforwardly modified for bioprinting and that the constructs obtained with the modified SLA printer show a high viability of patient‐derived cells. The bioprinted constructs mimic some key aspect of cholangiocarcinoma and are suitable for basic research ...
Louise Breideband, Kaja N. Wächtershäuser, Levin Hafa, Konstantin Wieland, Achilleas S. Frangakis, Ernst H. K. Stelzer, Francesco Pampaloni   +6 more
wiley   +1 more source

Global P2P BitTorrent Real-Time Traffic Over SDN-Based Local-Aware NG-PON2

IEEE Access, 2022
File sharing is one of the most common uses in Peer-to-peer (P2P) networks and structured P2P systems, such as BitTorrent (BT), which may overcome the limitations of features such as improved scalability, efficiency, and deterministic data location ...
I-Shyan Hwang, Ardian Rianto, Razat Kharga, Mohammad Syuhaimi Ab-Rahman   +3 more
doaj   +1 more source