Results 11 to 20 of about 1,458 (149)

Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons. [PDF]

Clin Transl Sci
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Srimatimanon T, Udomnilobol U, Chariyavilaskul P, Siwamogsatham S, Praditpornsilpa K, Vorasettakarnkij Y, Petchlorlian A, Vanwong N, Piriyapongsa J, Tipsombatboon P, Yodsurang V, Prueksaritanont T.   +11 more
europepmc   +2 more sources

Antiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma. [PDF]

Cancer Sci
Role of PON2 in regulating diverse molecular pathways influenced by PON2 during cancer progression and metastasis. Abstract Locally advanced oral squamous cell carcinoma poses a significant challenge in oncology due to its rising incidence and mortality rates. Despite therapeutic progress, understanding molecular intricacies is essential.
Kamal MV, Damerla RR, Parida P, Chakrabarty S, Rao M, Kumar NA.   +5 more
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

MicroRNA signature and integrative omics analyses define prognostic clusters and key pathways driving prognosis in patients with neuroendocrine neoplasms

Molecular Oncology, Volume 17, Issue 4, Page 582-597, April 2023., 2023
The comprehensive characterisation of microRNA (miRNA) profiles of neuroendocrine neoplasms has identified an eight‐miRNA signature able to stratify patients into three prognostic groups. Transcriptomic data have shown that these miRNAs are associated with genes involved in PI3K–Akt and TNFα–NF‐kB signalling.
Beatriz Soldevilla, Alberto Lens‐Pardo, Paula Espinosa‐Olarte, Carlos Carretero‐Puche, Sonia Molina‐Pinelo, Carlos Robles, Marta Benavent, Lourdes Gomez‐Izquierdo, Marta Fierro‐Fernández, Patricia Morales‐Burgo, Paula Jimenez‐Fonseca, Beatriz Anton‐Pascual, Yolanda Rodriguez‐Gil, Ana Teijo‐Quintans, Anna La Salvia, Beatriz Rubio‐Cuesta, Maria C. Riesco‐Martínez, Rocio Garcia‐Carbonero   +17 more
wiley   +1 more source

Distinct non‐coding RNA cargo of extracellular vesicles from M1 and M2 human primary macrophages

Journal of Extracellular Vesicles, Volume 11, Issue 12, December 2022., 2022
Abstract Macrophages are important antigen presenting cells which can release extracellular vesicles (EVs) carrying functional cargo including non‐coding RNAs. Macrophages can be broadly classified into M1 ‘classical’ and M2 ‘alternatively‐activated’ macrophages. M1 macrophages have been linked with inflammation‐associated pathologies, whereas a switch
Paschalia Pantazi, Toby Clements, Morten Venø, Vikki M. Abrahams, Beth Holder   +4 more
wiley   +1 more source

Upgrading a Consumer Stereolithographic 3D Printer to Produce a Physiologically Relevant Model with Human Liver Cancer Organoids

Advanced Materials Technologies, Volume 7, Issue 10, October 10, 2022., 2022
This work shows that an affordable consumer stereolithography apparatus (SLA) printer can be straightforwardly modified for bioprinting and that the constructs obtained with the modified SLA printer show a high viability of patient‐derived cells. The bioprinted constructs mimic some key aspect of cholangiocarcinoma and are suitable for basic research ...
Louise Breideband, Kaja N. Wächtershäuser, Levin Hafa, Konstantin Wieland, Achilleas S. Frangakis, Ernst H. K. Stelzer, Francesco Pampaloni   +6 more
wiley   +1 more source

l‐Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia

British Journal of Pharmacology, Volume 179, Issue 12, Page 3007-3023, June 2022., 2022
Background and Purpose Preeclampsia, characterized by hypertension, proteinuria and restriction of fetal growth, is one of the leading causes of maternal and perinatal mortality. So far, there is no effective pharmacological therapy for preeclampsia. The present study was conducted to investigate the effects of supplementation with l‐citrulline in Dahl
Andy W. C. Man, Yawen Zhou, Uyen D. P. Lam, Gisela Reifenberg, Anke Werner, Alice Habermeier, Ellen I. Closs, Andreas Daiber, Thomas Münzel, Ning Xia, Huige Li   +10 more
wiley   +1 more source

Software‐Defined Networks for Optical Networks Using Flexible Orchestration: Advances, Challenges, and Opportunities

Journal of Computer Networks and Communications, Volume 2022, Issue 1, 2022., 2022
Optical networks offer a wide range of benefits to the telecommunication sector worldwide with their provision of higher bandwidth, which leads to faster data speed, longer transmission distance, and improved latency. Currently, the complexity associated with advancements in optical networks poses problems to network flexibility, reliability, and ...
Kenneth Nsafoa-Yeboah, Eric Tutu Tchao, Bright Yeboah-Akowuah, Benjamin Kommey, Andrew Selasi Agbemenu, Eliel Keelson, Mohammad Monirujjaman Khan, Gianluigi Ferrari   +7 more
wiley   +1 more source

Pharmacological Effects and Underlying Mechanisms of Licorice‐Derived Flavonoids

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Glycyrrhizae Radix et Rhizoma is the most frequently prescribed natural medicine in China and has been used for more than 2,000 years. The flavonoids of licorice have garnered considerable attention in recent decades due to their structural diversity and myriad pharmacological effects, especially as novel therapeutic agents against inflammation and ...
Yufan Wu, Zhuxian Wang, Qunqun Du, Zhaoming Zhu, Tingting Chen, Yaqi Xue, Yuan Wang, Quanfu Zeng, Chunyan Shen, Cuiping Jiang, Li Liu, Hongxia Zhu, Qiang Liu, Jianping Chen   +13 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source