Results 51 to 60 of about 15,935,233 (246)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

474: lighting and thermal performance of innovative shading devices: new insights into their aesthetics and control in a Mediterranean climate [PDF]

, 2008
With a view towards minimising energy demand for cooling and artificial lighting in buildings, this paper evaluates innovative shading devices and how they can balance a generous degree of control mastering seasonal natural light with thermal gains in a ...
Passive & Low Energy Architecture (PLEA), Calleja, Herman, Buhagiar, Vincent, 25th Conference on Passive and Low Energy Architecture   +3 more
core  

The Hereford Screen: A Prehistory

, 2017
This paper explores two contexts for Francis Skidmore and George Gilbert Scott's screen at Hereford Cathedral. First, it locates the screen within a succession of choir screens at Hereford from the middle ages to the present, thereby charting the ...
The Hereford Screen: A Prehistory
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screen time in preschool-aged children [PDF]

Multidisciplinarni Pristupi u Edukaciji i Rehabilitaciji
The World Health Organization defines sedentary screen time as the time spent in passive screenbased entertainment (TV, computer, mobile phone), excluding active screen time, specifically time spent playing games requiring physical activity or movement ...
Ana Madžar Čančar, Slađana Ćalasan, Bojana Vuković, Sanja Živanović, Bojana Mastilo, Andrijana Bakoč, Ivana Zečević   +6 more
doaj   +1 more source

Screen time, family history and nutritional status of adolescents attended at a nursing clinic

, 2023
OBJECTIVE: To analyze the relationship between screen time, family history, nutritional status of adolescents assisted in the nursing consultation. METHOD: Quantitative, cross-sectional inferential study.
Maria do Amparo Silva Lima, Ana Virginia Rodrigues Veríssimo, Estela Maria leite Meirelles Monteiro, Iraneide Nascimento dos Santos, Raísa Helena do Nascimento Rodrigues   +4 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of Screen Time on Preschool Health and Development [PDF]

, 2019
Executive summary The rapid proliferation of personal technology has provided our children with unprecedented access to screen-based devices for both educational and entertainment purposes.
Stewart, T, Berry, S, Duncan, S, Walker, C, Schofield, G   +4 more
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source