Results 61 to 70 of about 15,289,136 (259)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Parenting and Child Behaviour Barriers to Managing Screen Time With Young Children

, 2021
The impact of excessive screen use on child health and development is now a public health concern, and research efforts are focused on finding ways to moderate screen use.
Morawska, Alina, Halpin, Samuel, Baker, Sabine, Mitchell, Amy E   +3 more
core   +1 more source

Screen use in children – two sides of the coin: a critical narrative review [PDF]

Dementia & Neuropsychologia
Like a coin, the impacts of screens on children’s development have two sides, as reflected in current scientific knowledge. This narrative review aimed to explore the dual-faceted state of the art regarding screen use, highlighting both positive and ...
Everton Ferreira de Souza, Rafael Antônio Vicente Lacerda, Janaína Aparecida Favero Desio, Camila Marciele Kammers, Silvana Henkes, Natasha Ferraz da Paixão Ribeiro, Monique Freitas de Sá, Driele Martins da Silva, Anna Carolina de Oliveira Resende Teixeira, Júlio César Claudino dos Santos   +9 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effects of Screen Time on Preschool Health and Development

, 2019
Executive summary The rapid proliferation of personal technology has provided our children with unprecedented access to screen-based devices for both educational and entertainment purposes.
Stewart, T, Berry, S, Duncan, S, Walker, C, Schofield, G   +4 more
core   +1 more source

Agreement between self-reported and objectively measured smartphone use among adolescents and adults

Computers in Human Behavior Reports
Almost everything we think we know about the prevalence, correlates, risks, and benefits of smartphone use is based on individuals’ self-reported estimates of use.
Kimberly M. Molaib, Xiaoran Sun, Nilam Ram, Byron Reeves, Thomas N. Robinson   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Evaluating the reading performance of semi-passive RFID tags to enhance locating of warehouse resources: An experiment design [PDF]

, 2011
Copyright @ 2011 8th European, Mediterranean and Middle Eastern Conference on Information Systems (EMCIS 2011)In the supply chain, a warehouse is a crucial component for linking all chain parties.
Aktas, E, Ali, M, Hassan, M
core   +4 more sources

The impact of passive screen time on early childhood speech and xml:language development: parental perspectives and behavioral correlates

Journal of Basic & Clinical Medical Sciences
Excessive and early exposure to digital screens has raised growing concerns about its implications for children’s speech and xml:language development. This study investigated the associations between passive screen exposure and speech and xml:language delays in children aged 5–8 years, focusing on behavioral and clinical risk factors such as screen-use
Muhammad Faizan, Hafiz Muhammad Hassan Zaman, Areej Zaman, Shumaila Malik, Aqsa Inayat   +4 more
openaire   +1 more source