Results 111 to 120 of about 13,458,883 (414)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The Supply Adjustment Process in Retail Space Markets [PDF]

open access: yes
Previous research has reported that the real estate market for retail space is slow to adjust, however, comparatively little research has investigated the supply of retail space for individual metropolitan markets.
Daniel T. Winkler   +2 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Qualitative Social Research in Spain: Past, Present, and Future. A Portrait

open access: yesForum: Qualitative Social Research, 2005
Cartographic work has always gone hand in hand with the effort for the advancement of knowl­edge in many fields. In this paper we will sketch a cartography of qualitative methodology in Spain.
Miguel S. Valles, Alejandro Baer
doaj  

The Effects of Housing Push Factors and Rent Expectations on Household Formation of Young Adults [PDF]

open access: yes
Following a group of young adults aged 25–34 living with their parents in the American Housing Survey (AHS) data from 1985 through 1995, this paper investigates the effect of overcrowding and neighborhood satisfaction on household formation after ...
Xiaodong Liu, Zhu Xiao Di
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Los futuros de México: encrucijada y clavos en el zapato Mexico's futures: crossroad and pain in the neck

open access: yesPolis, 2011
El artículo propone que México tiene pendiente la tarea de imaginar sus futuros de largo plazo, planteando que es urgente que lo haga en un esfuerzo colectivo, sistemático y riguroso.
Antonio Alonso Concheiro
doaj  

Cut & paste

open access: yes, 2005
In the system we use for recording and transmitting lectures over the Internet, the board content is transmitted as vector graphics, producing thus a high quality image, while the video of the lecturer is sent as a separate stream. It is easy for the viewer to read the board but the lecturer appears in a separate window.
Friedland, Gerald   +2 more
openaire   +2 more sources

Pricing Interest-Rate Risk for Mortgage REITs [PDF]

open access: yes
Using tax-qualified mortgage REITs over three periods (1976-79, 1980-82, and 1983-90), this paper investigates the pricing of interest-rate risk for mortgage REITs at equilibrium.
James R. Webb, Youguo Liang
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

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