Results 91 to 100 of about 5,255,194 (298)

Los futuros de México: encrucijada y clavos en el zapato Mexico's futures: crossroad and pain in the neck

open access: yesPolis, 2011
El artículo propone que México tiene pendiente la tarea de imaginar sus futuros de largo plazo, planteando que es urgente que lo haga en un esfuerzo colectivo, sistemático y riguroso.
Antonio Alonso Concheiro
doaj  

Anthropological Sense of History

open access: yesAntropologìčnì Vimìri Fìlosofsʹkih Doslìdžen'
Purpose. The paper’s main purpose is to establish the nature of the historical past’s reality and its presence in being. Theoretical basis. The author considers historical time as a factor in the identities of individuals and society. The past has a dual
A. V. Halapsis
doaj   +1 more source

MEMORY AS THE LANGUAGE BOUNDARY OF MODERN EUROPEAN PHILOSOPHY

open access: yesДискурс, 2017
In this paper we propose to consider the concept of memory in modern philosophy as an essential element of language of the philosophical systems of this period.
K. P. Shevtsov
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Время в Московской саге Василия Аксенова: Война и тюрьма

open access: yesPolilog: Studia Neofilologiczne, 2013
Time in Moscow Saga by Wasilij Aksionow: War and Prison This article is devoted to a problem of art time in the second of three books Moscow Saga by W. Aksionow. The book is titled War and Prison.
Irina Lach
doaj  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Visualizing Ontario's Indigenous Past

open access: yes, 2022
This project is made possible with funding by the Government of Ontario and through eCampusOntario’s support of the Virtual Learning Strategy.Visualizing Ontario's Indigenous Past is a Virtual simulation of life in the 16th Century Huron-Wendat City of ...
Carter, Michael   +4 more
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

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