Results 111 to 120 of about 4,524,183 (368)

Время в Московской саге Василия Аксенова: Война и тюрьма

open access: yesPolilog: Studia Neofilologiczne, 2013
Time in Moscow Saga by Wasilij Aksionow: War and Prison This article is devoted to a problem of art time in the second of three books Moscow Saga by W. Aksionow. The book is titled War and Prison.
Irina Lach
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Creating change through leadership development:

open access: yesJournal of the Canadian Health Libraries Association
In 2019, CHLA/ABSC launched the first Leadership Institute for health librarians in Canada. This article provides an overview of how the Leadership Institute (LI) was developed and delivered, the content and structure of the LI, lessons learned from ...
Miriam Ticoll, Sandy Iverson
doaj   +1 more source

Papuan Past Project

open access: yes, 2018
Le projet Papuan Past associe les approches archéologiques et génomiques afin d'étudier les modalités de peuplement et d’adaptation des populations – évolution biologiques, culturelles, et techniques – au cours des cinquante derniers millénaires en ...
editorsppp
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

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