Results 71 to 80 of about 2,738,754 (268)
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Grotesque and Southern Gothic in Cormac McCarthy’s Blood Meridian
Selçuk Üniversitesi Edebiyat Fakültesi Dergisi, 2019 This article offers a post-southernist reading that challenges and problematizes the impacts of haunted past of the American South with implications of violence embodied by Judge Holden in Cormac McCarthy’s Blood Meridian, or The Evening Redness in the ...
Hüseyin Altındiş
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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MEMORY AS THE LANGUAGE BOUNDARY OF MODERN EUROPEAN PHILOSOPHY
Дискурс, 2017 In this paper we propose to consider the concept of memory in modern philosophy as an essential element of language of the philosophical systems of this period.
K. P. Shevtsov
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
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Qualitative Social Research in Spain: Past, Present, and Future. A Portrait
Forum: Qualitative Social Research, 2005 Cartographic work has always gone hand in hand with the effort for the advancement of knowledge in many fields. In this paper we will sketch a cartography of qualitative methodology in Spain.
Miguel S. Valles, Alejandro Baer
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Polis, 2011 El artículo propone que México tiene pendiente la tarea de imaginar sus futuros de largo plazo, planteando que es urgente que lo haga en un esfuerzo colectivo, sistemático y riguroso.
Antonio Alonso Concheiro
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