Results 51 to 60 of about 4,524,183 (368)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
South Africa in the Eighties - An Individual view
South African Journal of Business Management, 1973 No abstract available.
A. T. Morkel
doaj +1 more source
, 2007 Past Mapping is two twenty meter long titanium sculptural objects on permenant display in the foyer of the Korean German Institute of Technology, Digital Media City, Seoul, South Korea In the art of the cartographer lies a tension between an objective ...
Wallen, LP
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Seneca in Search of Passing Time
Classica Cracoviensia, 2015 Seneca in Search of Passing Time Seneca shows us that reading the philosophers can enable the reader to escape time. He also teaches how to possess the future achieving fame among wise and virtuous people.
Elżbieta Wesołowska
doaj +1 more source
Resources for Understanding and Celebrating Juneteenth
, 2022 Histor
Not Even Past
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
PB Discussion Club. Image of the Future
Проект БайкалOn 30 January, regular and new participants of the PB Discussion Club gathered in the Green Sitting Room of the Irkutsk House of the Architect to discuss the theme of this issue.
Елена Григорьева +7 more
doaj +1 more source
O eterno retorno – a cultura portuguesa em tempos de crise, numa perspectiva musical
Studia Iberystyczne, 2015 Even in times of crisis, the extraordinary linguistic variety (signaled) in Portugal does not oppose the prevalence of the Portuguese language and a near complete understanding between speakers of different regions, nor does it appear as an element of a
Marcos Nunes de Vilhena
doaj +1 more source