Results 41 to 50 of about 10,879,165 (319)

South Africa in the Eighties - An Individual view

open access: yesSouth African Journal of Business Management, 1973
No abstract available.
A. T. Morkel
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Seneca in Search of Passing Time

open access: yesClassica Cracoviensia, 2015
Seneca in Search of Passing Time Seneca shows us that reading the philosophers can enable the reader to escape time. He also teaches how to possess the future achieving fame among wise and virtuous people.
Elżbieta Wesołowska
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PB Discussion Club. Image of the Future

open access: yesПроект Байкал
On 30 January, regular and new participants of the PB Discussion Club gathered in the Green Sitting Room of the Irkutsk House of the Architect to discuss the theme of this issue.
Елена Григорьева   +7 more
doaj   +1 more source

O eterno retorno – a cultura portuguesa em tempos de crise, numa perspectiva musical

open access: yesStudia Iberystyczne, 2015
Even in times of crisis, the extraordinary linguistic variety (signaled) in Portugal does not oppose the prevalence of the Portuguese language and a near complete understanding between speakers of different regions, nor does it appear as an element of a
Marcos Nunes de Vilhena
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

On the future of architecture

open access: yesПроект Байкал
In postavantgarde culture, the future has become an object of desire and obvious value. The uncontested belief that every new thing should be accepted as an undoubted good lies at the heart of numerous utopias and speculations.
Александр Раппапорт
doaj   +1 more source

Does our Past have a Motivational Effect? Our Reasons for Acting: Sartre’s Philosophy of Action

open access: yesEthics in Progress, 2013
The goal of my paper is to consider how one chooses one’s own action. First, I will try to understand how both his past and his environment can condition someone's action.
Yoann Malinge
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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