Results 61 to 70 of about 2,738,754 (268)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Professor Yücel Tümer, MD; a legend, mentor in children’s orthopaedics in Turkey
Acta Orthopaedica et Traumatologica Turcica, 2021 Hakan Ömeroğlu, Muharrem Yazıcı
doaj +1 more source
Наука телевидения, 2017 This article is about the interpretation of national history in the context of universal history, which was begun by Karamzin and continued by Granovsky and Kliuchevskoi.
ZHUKOVA O.A. / ЖУКОВА О.А.
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Il Capitale Culturale: Studies on the Value of Cultural Heritage, 2019 Il paper presenta il modello dell’Area archeologica di Poggio del Molino a Populonia (Piombino, LI) attraverso l’intervento dell’Associazione culturale Past in Progress che ha, nel tempo, acquisito una grande rilevanza, soprattutto a livello ...
Stefano Monti, Carolina Megale
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Generating hope in pastoral care through relationships
HTS Teologiese Studies/Theological Studies, 2012 This article concerned itself with the notion of Christian hope, in the midst of suffering, where this hope will find its energy from within a relationship with God and his people.
Tobias H. Steyn, Maake J. Masango
doaj +1 more source