Results 1 to 10 of about 128,744 (144)

In-process analytics for IVT mRNA manufacturing: from process understanding to advanced process control [PDF]

Frontiers in Bioengineering and Biotechnology
RNA therapeutics are expanding rapidly, driving demand for manufacturing processes that can keep pace with clinical translation. Because mRNA yield and impurity profiles are jointly influenced by upstream plasmid DNA (pDNA) preparation and the in vitro ...
Naryeong Kim, Emily Dong, Kate Tschudi, Julien Camperi   +3 more
doaj   +2 more sources

Current PAT Landscape in the Downstream Processing of Biopharmaceuticals [PDF]

Analytical Science Advances
Protein‐based therapeutics have revolutionized modern medicine, addressing complex diseases with unprecedented specificity and efficacy. The rising demand for biologics has driven the evolution of biomanufacturing practices to ensure consistent quality ...
Pavithra Sathiyapriyan, Shatanik Mukherjee, Thomas Vogel, Lars‐Oliver Essen, David Boerema, Martin Vey, Uwe Kalina   +6 more
doaj   +2 more sources

Non-invasive instrumental analytical methods in modern pharmaceutical technology [PDF]

Farmacja Polska, 2020
The purpose of this work is the evaluation of the state of knowledge in the scope of the possibility of using of non-invasive analytical methods in the implementation of Process Analytical Technology strategy, which is currently recommended by worldwide ...
Joanna Ronowicz, Natalia Piekuś-Słomka
doaj   +1 more source

On-Line Real-Time Monitoring of a Rapid Enzymatic Oil Degumming Process: A Feasibility Study Using Free-Run Near-Infrared Spectroscopy

Foods, 2021
Enzymatic degumming is a well established process in vegetable oil refinement, resulting in higher oil yield and a more stable downstream processing compared to traditional degumming methods using acid and water. During the reaction, phospholipids in the
Jakob Forsberg, Per Munk Nielsen, Søren Balling Engelsen, Klavs Martin Sørensen   +3 more
doaj   +1 more source

Real-time quality control for chemical and biotechnological processes: a brief review

Journal of Medical Science, 2023
Monitoring critical process parameters of chemical and biotechnological processes is an essential tool at every stage of drug manufacturing technology.
Agnieszka Kołodziejczak-Radzimska, Beata Rukowicz, Sharon Davin   +2 more
doaj   +1 more source

Fast and Non-Invasive Evaluation of Yeast Viability in Fermentation Processes Using Raman Spectroscopy and Machine Learning

Beverages, 2023
Fermentation processes used for producing alcoholic beverages such as beer, wine, and cider have a long history, having been developed early on across different civilizations. In most instances, yeast strains are used for fermentation processes, e.g., at
Raoul Heese, Jens Wetschky, Carina Rohmer, Susanne M. Bailer, Michael Bortz   +4 more
doaj   +1 more source

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

Pharmaceutics, 2021
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry.
Eun Ji Kim, Ji Hyeon Kim, Min-Soo Kim, Seong Hoon Jeong, Du Hyung Choi   +4 more
doaj   +1 more source

The Rocky Road to a Digital Lab

CHIMIA, 2023
The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs).
Peter Sagmeister, Jason D. Williams, C. Oliver Kappe   +2 more
doaj   +1 more source

In Situ Quantification of Polyhydroxybutyrate in Photobioreactor Cultivations of Synechocystis sp. Using an Ultrasound-Enhanced ATR-FTIR Spectroscopy Probe

Bioengineering, 2021
Polyhydroxybutyrate (PHB) is a very promising alternative to most petroleum-based plastics with the huge advantage of biodegradability. Biotechnological production processes utilizing cyanobacteria as sustainable source of PHB require fast in situ ...
Philipp Doppler, Christoph Gasser, Ricarda Kriechbaum, Ardita Ferizi, Oliver Spadiut   +4 more
doaj   +1 more source

Process analytical technology (PAT) for biopharmaceuticals [PDF]

, 2011
Process analytical technology (PAT), the regulatory initiative for building in quality to pharmaceutical manufacturing, has a great potential for improving biopharmaceutical production.
Bruggeman, Clementschitsch, Clementschitsch, Coleman, Cunha, Dassau, Degerman, Farid, Feng, Gabrielsson, Gawlitzek, Gernaey, Gernaey, Kell, Kiparissides, Kourti, Lennox, Lenz, Li, Mandenius, Martin, Morrow, Navratil, Nomikos, Noorman, Petrides, Rathore, Rhee, Roels, Sayar, Sin, Sin, Sin, Singh, Striedner, Striedner, Teixeira, Teixeira, Werner, Wong, Wurm, Ödman   +41 more
core   +1 more source