Results 161 to 170 of about 326,331 (291)

Serotonin depletion amplifies migraine susceptibility through trigeminal ganglion neurons sensitization: Insights from patch clamp recordings in rat model. [PDF]

PLoS One
Vongseenin S, Thanprasertsuk S, Ha-Ji-A-Sa N, Bongsebandhu-Phubhakdi S.   +3 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation. [PDF]

ACS Chem Neurosci
Rodriguez L, Diedrich J, Sun L, Tsu B, Kairs S, Vlkolinsky R, Barnes CA, Martins AMA, Roberto M, Yates JR.   +9 more
europepmc   +1 more source

The pivotal role of impedance in patch clamp technique

, 2017
Impedance is pivotal when we talk about patch clamp technique which is a unique innovation in the field of knowing channels in vivo and have proved to make a promising difference therapeutically.
Shahbaz, K
core  

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Challenges and Insights in Patch-Clamp Studies: From Cell-Attached to Whole-Cell Configurations. [PDF]

Curr Issues Mol Biol
Wu SN, Wang YJ, Liutkevičienė R.
europepmc   +1 more source

Patch-clamp technique to study mitochondrial membrane biophysics. [PDF]

J Gen Physiol, 2023
Kumari A, Nguyen DM, Garg V.
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans. [PDF]

Neuro Oncol
Tong T, Hendriksen JD, Elbæk KJ, Molnar K, Christiansen FV, Ozsvar A, Eschen JT, Rodríguez-González FG, Pusat ID, Christensen EL, Rahbæk M, Frederiksen KP, Cortnum SOS, Sindby AK, Meier K, Nikola, Sørensen JCH, Ting JT, Capogna M, Kristensen BW, Nyengaard JR, Weischenfeldt J, Hou WH, Korshøj AR.   +23 more
europepmc   +1 more source

Whole-cell patch-clamp recording and parameters. [PDF]

Biophys Rev, 2023
Kodirov SA.
europepmc   +1 more source