Results 201 to 210 of about 326,331 (291)

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording. [PDF]

Adv Sci (Weinh)
Yang S, Xue J, Li Z, Zhang S, Zhang Z, Huang Z, Yung KKL, Lai KWC.   +7 more
europepmc   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Automated patch clamp analysis of heterologously expressed Kir6.2/SUR1 and Kir6.1/SUR2B K_ATP currents. [PDF]

Am J Physiol Cell Physiol
Li K, Janve VS, Denton JS.
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Correction: DeepGANnel: Synthesis of fully annotated single molecule patch-clamp data using generative adversarial networks. [PDF]

PLoS One
Ball STM, Celik N, Sayari E, Abdul Kadir L, O'Brien F, Barrett-Jolley R.   +5 more
europepmc   +1 more source

Design Rules for Quantitative Control of Intragrain Planar Defects in Halide Perovskites

Advanced Science, EarlyView.
Dose‐budgeted electron microscopy reveals the design rules governing intragrain planar defects in halide perovskites: {112}t ferroelastic twins proliferate with increasing tetragonality and grain size, whereas {111}c twins and stacking faults emerge as the lattice approaches cubic symmetry.
Byeongjun Gil, So Jeong Park, Jin Young Kim, Miyoung Kim   +3 more
wiley   +1 more source

Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices. [PDF]

Sci Rep
Alvarez Baron C, Zhao J, Yu H, Ren M, Thiebaud N, Guo D, Vegesna G, Hsiao CH, DePalma R, Mistry S, Tariq I, Roni MSR, Ismaiel OA, Matta MK, Patel V, Mashaee M, Vicente J, Johannesen L, Sheng J, Hebeisen S, Kramer J, Bruening-Wright A, Nakano K, Matsukawa H, Pierson JB, Wu WW.   +25 more
europepmc   +1 more source

A Modular Variable Stiffness Co‐Bot System Achieving Tasks Flexibility and Contact Compliance

Advanced Science, EarlyView.
Bio‐inspired antagonistic compliance enables a modular rigid‐soft co‐bot platform with variable stiffness for safe human‐robot interaction (HRI): Standardized interfaces support application‐driven configurations with tailored DoFs, workspace, and stiffness range, making the system suited to HRI and low‐volume automation.
Wenlong Gaozhang, Yue Li, Jialei Shi, Yaxi Wang, Kaspar Althoefer, Agostino Stilli, Helge A. Wurdemann   +6 more
wiley   +1 more source

Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements. [PDF]

Front Physiol
Syren P, Zlatopolskaia A, Bruehl C, Schöffel A, Caspari T, Heß C, Frey N, Thomas D, Lugenbiel P.   +8 more
europepmc   +1 more source