Results 111 to 120 of about 5,720,247 (293)
Imaging single-channel calcium microdomains by total internal reflection microscopy
Biological Research, 2004 The microdomains of Ca2+ in the cytosol around the mouth of open Ca2+ channels are the basic `building blocks' from which cellular Ca2+ signals are constructed.
ANGELO DEMURO, IAN PARKER
doaj
STAR ProtocolsSummary: Multiple patch-clamp recordings and morphological reconstruction are powerful approaches for neuronal microcircuitry dissection and cell type classification but are challenging due to the sophisticated expertise needed.
Yuying Shi, Guangfu Wang
doaj +1 more source
Flexoelectricity in Photoconversion: Fundamentals, Materials, and Outlooks
Advanced Science, EarlyView.Mechanical bending of a flexible cantilever induces a strain gradient in the photoactive material. The resulting flexoelectric field couples with photovoltaic and photoconductive effects, modulating charge generation, separation, and collection. A comparative analysis of oxide perovskites, halide perovskites, and two‐dimensional materials is presented,
Xiang Huang, Feng Li, Rongkun Zheng
wiley +1 more source
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Investigation of the role of afterhyperpolarizaÜon potential in the formation of the electrical signals in some brain cells of mouse, rat and helix aspersa [PDF]
Eurasian Journal of Veterinary SciencesIn this study, using the double and sharp microelectrodes and patch clamp techniques, intracellular recordings were performed in the neurons of mice cochlear nucleus, rat inferior colliculus and subesophagial ganglia ol Helix aspersa in vitro.
Ramazan Bal
doaj
Planar patch clamp for neuronal networks - Considerations and future perspectives
, 2014 The patch-clamp technique is generally accepted as the gold standard for studying ion channel activity allowing investigators to either "clamp" membrane voltage and directly measure transmembrane currents through ion channels, or to passively monitor ...
Bosca, Alessandro +5 more
core +1 more source
Machine Learning of Temperature‐Dependent Chemical Kinetics Using Parallel Droplet Microreactors
Advanced Science, EarlyView.An integrated droplet microfluidics and machine learning framework enables high‐throughput characterization of temperature‐dependent reaction kinetics. Time‐resolved measurements from thousands of droplets train Neural ODE models that accurately predict nonlinear reaction dynamics across diverse thermal environments, bridging large‐scale ...
Mamoru Saita, Yutaka Hori
wiley +1 more source
History of electrophysiology and the patch clamp
, 2014 We provide a historic outlook on the development of the concept of bioelectricity, with emphasis on the neuromuscular junction as a model that revolutionized our thinking of the nerve, nervous, and muscle tissue excitability.
Vladimir Parpura +3 more
core +1 more source