A simulative evaluation of triply periodic minimal surface (TPMS) structures for an elastocaloric application under compressive load is performed. For the evaluation of the structure's performance, surface/volume ratio, generated heat and invested mechanical work are taken into account and are compared to a tube as a reference specimen.
Michael Fries+3 more
wiley +1 more source
Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents [PDF]
The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds and ...
Bruno Blanch, Luis Enrique+8 more
core +2 more sources
Reliable Tissue Grasping in Robotic Minimally Invasive Surgery Enabled by Optical‐Based Slip Sensing
An optical‐based slip sensing method using a complementary metal–oxide–semiconductor image sensor with a built‐in infrared light emitting diode enables real‐time detection of tissue slippage—including displacement, direction, and speed—in robotic minimally invasive surgery.
Minjae Lee, Amy Kyungwon Han
wiley +1 more source
Patch-Clamp Analysis of the Mitochondrial H+ Leak in Brown and Beige Fat
Mitochondria convert the chemical energy of metabolic substrates into adenosine triphosphate (ATP) and heat. Although ATP production has become a focal point of research in bioenergetics, mitochondrial thermogenesis is also crucial for energy metabolism.
Ambre M. Bertholet, Yuriy Kirichok
doaj +1 more source
A geographically distributed bio-hybrid neural network with memristive plasticity [PDF]
Throughout evolution the brain has mastered the art of processing real-world inputs through networks of interlinked spiking neurons. Synapses have emerged as key elements that, owing to their plasticity, are merging neuron-to-neuron signalling with ...
Corna, Andrea+10 more
core +1 more source
Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator
Finding the silent skipped beat: Predicting arrhythmia-causing drugs using a high-throughput hybrid heart simulator. To save time and cost for drug discovery, a paradigm shift in cardiotoxicity testing is required.
J. Okada+7 more
semanticscholar +1 more source
3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht+5 more
wiley +1 more source
Modulation of a sustained calcium current by intracellular pH in horizontal cells of fish retina. [PDF]
A sustained high voltage-activated (HVA), nifedipine- and cadmium-sensitive calcium current and a sustained calcium action potential (AP) were recorded from horizontal cells isolated from catfish retina.
Copenhagen, DR, Dixon, DB, Takahashi, K
core
Low‐dimensional halide perovskite thin films, (BA)2(MA)n‐1PbnBr3n+1 (n = 1, 2), exhibit both semiconducting and ferroelectric properties, enabling mechanical and light energy harvesting. Using Cr/Cr₂O₃ or PCBM as barrier layers ensures reproducible ferroelectricity.
Raja Sekhar Muddam+8 more
wiley +1 more source
Scorpion Venom peptide, AGAP inhibits TRPV1 and potentiates the analgesic effect of lidocaine
The current study was designed to test the hypothesis that BmK AGAP (AGAP) potentiates the analgesic effect of lidocaine. The chronic constrictive injury was performed on 72 rats to induce a rapid onset and long-lasting pain.
Sylvanus Kampo+6 more
doaj