Results 301 to 310 of about 752,311 (360)

Genetic Impacts on the Structure and Mechanics of Cellulose Made by Bacteria

Advanced Science, EarlyView.
A genetic mutation in a protease of a cellulose‐overproducing evolved bacterium significantly affects the proteome, structure, and mechanical properties of bio‐fabricated cellulose pellicles. By overexpressing synthase proteins that build the cellulose‐forming biological machinery of the cell, the evolved bacterium generates dense, stiff, and strong ...
Julie M. Laurent, Mathias Steinacher, Anton Kan, Maximilian Ritter, Mario Leutert, Siiri Bienz, David Häberlin, Naresh Kumar, André R. Studart   +8 more
wiley   +1 more source

An Amygdala‐hippocampus Circuit for Endocannabinoid Modulation of Anxiety Avoidance

Advanced Science, EarlyView.
This study employs three synapse‐specific endocannabinoids (eCB) probes to monitor dynamic eCB release, activate CB1Rs and knockdown 2‐AG biosynthesis enzymes in glutamatergic anterior basolateral amygdala ‐ ventral hippocampus (aBLA–vHPC) circuit. At aBLA–vHPC circuits, activation of CB1Rs reduce anxiety avoidance, and knockdown of eCB biosynthesis ...
Bao Xue, Mao‐Xing Zhang, Xiao‐Chen Bi, Shou‐Peng Lai, Xin‐Tian Bie, Yuan Dong, Jian‐Feng Li, Fang Gao, Xia Zhang, Ying Wang   +9 more
wiley   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source

Single-Cell Patch-Clamp/Proteomics of Human Alzheimer's Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets. [PDF]

Adv Sci (Weinh)
Ghatak S, Diedrich JK, Talantova M, Bhadra N, Scott H, Sharma M, Albertolle M, Schork NJ, Yates JR, Lipton SA.   +9 more
europepmc   +1 more source

Ultra‐Low Hysteresis Under Large Deformation Enabled by Fast Chains Relaxation in Highly Competitive Dynamic Hydrogen Bond Networks

Advanced Science, EarlyView.
This study demonstrates that incorporating deep eutectic solvent (DES) components tunes the relaxation dynamics of strong hydrogen bonds between polymer segments, rendering them mechanically “invisible” during service conditions (low hysteresis: <3%).
Shuaijun Guo, Shilei Zhu, Yang Qiao, Shanhao Feng, Xin Yang, Beibei Kang, Chaojun Yue, Yanjing Zhang, Zhuangzhuang Li, Ya Nan Ye, Qiang Zheng   +10 more
wiley   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

Advanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez, Maria Virginia Giolito, Sultan Al‐Siyabi, Kristian Serafimov, Florine Laloux, Emeline Dierge, Léo Aubert, Céline Guilbaud, Selena Kaye, Paula Varon, Dorothée Marchand, Hanne Vlieghe, Emmanuel Hermans, Caroline Bouzin, Davide Brusa, Christiani Andrade Amorim, Barabara Pachikian, Yvan Larondelle, Cyril Corbet, Chantal Dessy, Olivier Feron   +20 more
wiley   +1 more source

In situ monolayer patch clamp of acutely stimulated human iPSC-derived cardiomyocytes promotes consistent electrophysiological responses to SK channel inhibition. [PDF]

Sci Rep
Butler AS, Ascione R, Marrion NV, Harmer SC, Hancox JC.   +4 more
europepmc   +1 more source

Flame‐Retardant Ionogel Enabled by Lignin Molecular Networks for Fire Rescue

Advanced Science, EarlyView.
Wearable sensors for harsh, high‐temperature, fire‐prone environments face challenges in heat resistance and stability. This study introduces a flame‐retardant, waterproof glycol lignin ionogel (GLI) with a robust 3D network, exceptional tensile strength, strong adhesion, biocompatibility, eco‐safety, and dual temperature‐motion sensing, even after ...
Zewei Ye, Haomeng Yu, Hongxia Xie, Wenwen Zhu, Shitao Shi, Chencong Liu, Yuanyuan Wang, Jiaqi Liao, Qingfeng Sun, Dawei Zhao, Xiaoping Shen   +10 more
wiley   +1 more source

Loose-patch clamp analysis applied to voltage-gated ionic currents following pharmacological ryanodine receptor modulation in murine hippocampal cornu ammonis-1 pyramidal neurons. [PDF]

Front Physiol
Bertagna F, Ahmad S, Lewis R, Silva SRP, McFadden J, Huang CL, Matthews HR, Jeevaratnam K.   +7 more
europepmc   +1 more source

Deterministic Fabrication of Plasmonic Nanostructures on Optical Nanofibers via Blurred Electron Beam Deposition

Advanced Science, EarlyView.
A nanofabrication method enabling the direct growth of plasmonic nanostructures are presented on suspended tapered optical nanofibers via Blurred Electron Beam Induced Deposition (BEBID). By defocusing the beam to reduce mechanical stress, BEBID achieves sub‐20 nm precision and structural control, enabling directional scattering and light–matter ...
Antonio Balena, Marianna D'Amato, Muhammad Fayyaz Kashif, Chengjie Ding, Lucien Belzane, Gaia De Marzo, Hanna Le Jeannic, Massimo De Vittorio, Ferruccio Pisanello, Alberto Bramati   +9 more
wiley   +1 more source