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Electronic Design of the Patch Clamp
1983The patch-clamp amplifier is fundamentally a sensitive current-to-voltage converter, converting small (picoampere to nanoampere) pipette currents into voltage signals that can be observed with an oscilloscope or sampled by a computer. This chapter describes the basic principles of the current-to-voltage (I–V) converter and describes some of the ...
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Expert Opinion on Drug Discovery, 2018
Alison Obergrussberger +11 more
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Alison Obergrussberger +11 more
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Advances in the automation of whole-cell patch clamp technology
Journal of Neuroscience Methods, 2019Ho‐Jun Suk, E. Boyden, I. V. Welie
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Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes
Nature Protocols, 2017Cheng-Chang Chen +8 more
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Patch Clamp Technique and Applications
2017There are two main modes in patch clamp recordings: voltage clamp and current clamp. In the voltage clamp mode, the membrane voltage is controlled by the amplifier through the recording pipette and the corresponding current through the pipette is measured.
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