Results 131 to 140 of about 16,362,977 (342)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The Role of Contact Allergens on Facial Seborrheic Dermatitis

Cyprus Journal of Medical Sciences
BACKGROUND/AIMS: Seborrheic dermatitis (SD) is an inflammatory skin condition characterised by scaly erythematous patches. The causes of SD include inflammatory reaction to Malassezia species, genetic predisposition and hormonal factors; however, any ...
Gülfem Ünsal, İçim Kömürcügil, Nermin Karaosmanoğlu   +2 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The role of sensitization to birch polen allergens in the development of acute atopic dermatitis in patients living in Moscow and the Moscow region

Медицинская иммунология
Atopic dermatitis (AD) is a chronic inflammatory skin disease, its pathogenesis is associated with immunological disorders and genetically determined defects of the epidermal barrier.
O. G. Elisyutina, E. V. Smolnikov, A. O. Litovkina, D. D. Chernuchevich, E. S. Fedenko   +4 more
doaj   +1 more source

A database of human predictive patch test data for skin sensitization. [PDF]

Arch Toxicol, 2023
Strickland J, Abedini J, Allen DG, Gordon J, Hull V, Kleinstreuer NC, Ko HS, Matheson J, Thierse HJ, Truax J, Vanselow JT, Herzler M.   +11 more
europepmc   +1 more source

Atopy patch test

Indian Journal of Dermatology, Venereology and Leprology, 2019
Varsha, Vaidyanathan, Aarti, Sarda, Abhishek, De, Sandipan, Dhar   +3 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Knowledge-based design of generate-and-patch problem solvers that solve global resource assignment problems [PDF]

We present MENDER, a knowledge based system that implements software design techniques that are specialized to automatically compile generate-and-patch problem solvers that satisfy global resource assignments problems.
Voigt, Kerstin
core   +1 more source

Irritation Test of Cream Preparations Made from Purple Cabbage Extract Against Healthy Skin Using The Path Test Method

Jurnal Info Kesehatan
Testing for skin irritation caused by new substances is a critical component of safety evaluation procedures. Pharmaceutical formulations and active ingredients intended for topical application have the potential to cause skin irritation, necessitating ...
Deswani Deswani, Sri Djuwitaningsih, Harpolia Cartika, Paul Malau   +3 more
doaj   +1 more source