Results 161 to 170 of about 14,199,958 (398)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Clinical Relevance of Contact Allergy to Gold Sodium Thiosulphate in Fibromyalgia

Acta Dermato-Venereologica
Fibromyalgia is a chronic syndrome characterized by pain, fatigue, and cognitive disturbances. The increased prevalence of contact allergy to gold in individuals with fibromyalgia when compared with the general population has previously been described ...
Katharine Hopkins, Annarita Antelmi, Jakob Dahlin, Karin Olsson, Cecilia Svedman, Jacqueline Åstrand, Peter Olsson, Magnus Bruze   +7 more
doaj   +1 more source

Usefulness of dermoscopy in the evaluation of patch test reactions. [PDF]

An Bras Dermatol, 2021
Oppermann K, Cattani CAS, Bonamigo RR.
europepmc   +1 more source

Managing the excited skin syndrome: patch testing hyperirritable skin [PDF]

, 1997
John C. Mitchell, Howard I. Maibach
openalex   +1 more source

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

The role of the atopy patch test in the diagnostic work-up of non-IgE gastrointestinal food allergy in children: a systematic review. [PDF]

Eur J Pediatr, 2023
Cuomo B, Anania C, D'Auria E, Decimo F, Indirli GC, Manca E, Marseglia GL, Mastrorilli V, Panetta V, Santoro A, Sartorio MUA, Veronelli E, Calvani M.   +12 more
europepmc   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Parameter-Efficient Fine-Tuning with Attributed Patch Semantic Graph for Automated Patch Correctness Assessment [PDF]

arXiv
Automated program repair (APR) aims to automatically repair program errors without human intervention, and recent years have witnessed a growing interest on this research topic. While much progress has been made and techniques originating from different disciplines have been proposed, APR techniques generally suffer from the patch overfitting issue, i ...
arxiv  

Application of the Brazilian patch test panel in the diagnosis of allergic contact dermatitis to cosmetics. [PDF]

An Bras Dermatol, 2022
Villarinho ALCF, Melo MDGM, Teixeira LR.
europepmc   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source