Results 171 to 180 of about 226,989 (311)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Evaluating the Efficacy of Soothing Agents in Mitigating 0.1% Retinol-Induced Skin Irritation: A Patch Test. [PDF]

J Cosmet Dermatol
Ying Y, Fang Y, Chenlan X, Lin S, Jiefang H, Yanan L, Peiwen S.   +6 more
europepmc   +1 more source

The role of the atopy patch test in the diagnostic work-up of non-IgE gastrointestinal food allergy in children: a systematic review. [PDF]

Eur J Pediatr, 2023
Cuomo B, Anania C, D'Auria E, Decimo F, Indirli GC, Manca E, Marseglia GL, Mastrorilli V, Panetta V, Santoro A, Sartorio MUA, Veronelli E, Calvani M.   +12 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Patch Test Preparations: Basis and State-of-the-Art Modern Diagnostic Tools for Contact Allergy. [PDF]

J Clin Med
Zimmer J, Neimanis S, Schmidt S, Schubert S, Mahler V.   +4 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Patch test results in a Dutch paediatric population with suspected contact allergy: A retrospective cohort study. [PDF]

Contact Dermatitis, 2023
Barwari L, Rustemeyer T, Franken SM, Ipenburg NA.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Skin Prick Test and Patch Test: Environmental and Chemical Allergen Reactivity Pattern Among Yemeni Patients in Sana'a City, Yemen. [PDF]

J Asthma Allergy
Al-Ghoury AA, Obaid JMAS, Ali WA, Al-Shaybani MA.   +3 more
europepmc   +1 more source

Effects of dupilumab treatment on patch test reactions: A retrospective evaluation. [PDF]

Clin Exp Allergy, 2021
de Wijs LEM, van der Waa JD, Nijsten T, Silverberg JI, Kunkeler ACM, Hijnen DJ.   +5 more
europepmc   +1 more source