Results 191 to 200 of about 226,989 (311)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Prevalence of Contact Allergy to Propolis-Testing With Different Propolis Patch Test Materials. [PDF]

Contact Dermatitis
Antelmi A, Trave I, Gallo R, Cozzani E, Parodi A, Bruze M, Svedman C.   +6 more
europepmc   +1 more source

Evaluation of Patch Test Results in Paediatric Patients in a Tertiary Dermatology Clinic.

Indian J Dermatol, 2023
Kazan D, Odyakmaz-Demirsoy E, Eloglu H, Kiran R.   +3 more
europepmc   +1 more source

Recurrent Acute Generalized Exanthematous Pustulosis to Two Different Drugs: Oxacillin and Dextromethorphan Confirmed by Patch Test. [PDF]

Dermatol Pract Concept, 2022
Kenani Z, Gammoudi R, Fathallah N, Aounallah A, Mokni S, Boussofara L, Ghariani N, Belajouza C, Ben Salem C, Denguezli M.   +9 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Transcriptomic Analysis of Allergic Patch Test Reactions in Non-Atopic Patients: A Comparative Study Across Multiple Allergens. [PDF]

Allergy
Pesqué D, Andrades E, Berenguer-Molins P, Perera-Bel J, Clarós M, Bódalo-Torruella M, González-Farré M, Gallardo F, Pujol RM, Giménez-Arnau AM.   +9 more
europepmc   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Epidemiological Comparative Study on Contact Sensitisations in Woodworkers With Occupational Dermatitis: Patch Test Data of the Information Network of Departments of Dermatology, 1999 to 2023. [PDF]

Contact Dermatitis
Heizmann L, Schubert S, Bauer A, Becker D, Brockow K, Dickel H, Kränke B, Lang C, Oppel E, Wagner N, Weisshaar E, Wilfinger D, Brans R, IVDK.   +13 more
europepmc   +1 more source

Patch test of dental materials in Oral Lichen Planus with considering the role of saliva. [PDF]

Sci Rep, 2021
Agha-Hosseini F, Gholamrezayi E, Moosavi MS.   +2 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source