Results 91 to 100 of about 199,906 (316)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer.

PLoS ONE, 2018
The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously ...
Genovefa Polychronidou, Vassiliki Kotoula, Kyriaki Manousou, Ioannis Kostopoulos, Georgia Karayannopoulou, Eleni Vrettou, Mattheos Bobos, Georgia Raptou, Ioannis Efstratiou, Dimitrios Dionysopoulos, Kyriakos Chatzopoulos, Sotirios Lakis, Sofia Chrisafi, Dimitrios Tsolakidis, Alexios Papanikolaou, Nikolaos Dombros, George Fountzilas   +16 more
doaj   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Resilient method for recovering coverage holes of wireless sensor networks by using mobile nodes

Tongxin xuebao, 2011
Coverage holes directly reduce network performance and become a key problem of static wireless sensor net-works.A hole-patching method was presented to get the resilient coverage,in which mobile nodes were guided by the boundary nodes of the coverage ...
WANG Liang-min1, LI Fei1, QIN Ying 1
doaj   +2 more sources

IMAGE SYNTHESIS OF METAL FOAM MICRO-STRUCTURE WITH THE USE OF WANG TILES

Acta Polytechnica CTU Proceedings, 2018
In this paper we present our recent work focused on the analysis of the abilities of Wang Tiles method and Automatic tile design method to synthesize the micro-structure of cellular materials, especially particular type of metal foam.Wang Tiles method ...
Lukáš Zrůbek, Martin Doškář, Anna Kučerová, Marcela Meneses-Guzmán, Francisco Rodríguez-Méndez, Bruno Chiné   +5 more
doaj   +1 more source

Surface-effect corrections for solar-like oscillations using 3D hydrodynamical simulations

, 2015
The space-borne missions have provided us with a wealth of high-quality observational data that allows for seismic inferences of stellar interiors. This requires the computation of precise and accurate theoretical frequencies, but imperfect modeling of ...
Belkacem, K., Caffau, E., Ludwig, H. -G., Mosser, B., Samadi, R., Sonoi, T.   +5 more
core   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Analyzing Android Browser Apps for file:// Vulnerabilities

, 2014
Securing browsers in mobile devices is very challenging, because these browser apps usually provide browsing services to other apps in the same device. A malicious app installed in a device can potentially obtain sensitive information through a browser ...
Chang, Rocky K. C., Wu, Daoyuan
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Patched Knockout Mouse Models of Basal Cell Carcinoma

Journal of Skin Cancer, 2012
Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system ...
Frauke Nitzki, Marco Becker, Anke Frommhold, Walter Schulz-Schaeffer, Heidi Hahn   +4 more
doaj   +1 more source