Results 71 to 80 of about 35,849 (293)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Resilient method for recovering coverage holes of wireless sensor networks by using mobile nodes
Tongxin xuebao, 2011 Coverage holes directly reduce network performance and become a key problem of static wireless sensor net-works.A hole-patching method was presented to get the resilient coverage,in which mobile nodes were guided by the boundary nodes of the coverage ...
WANG Liang-min1, LI Fei1, QIN Ying 1
doaj +2 more sources
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
, 2011 International audienceTools have been designed to detect for faults in the Linux Kernel, such as Coccinelle, Sparse, or Undertaker, and studies of their results over the vanilla tree have been published. We are interested in a specific point: since Linux
Martineau, Patrick, Lissy, Alexandre
core +1 more source
PLoS ONE, 2018 The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously ...
Genovefa Polychronidou +16 more
doaj +1 more source
Stem Cell Reports, 2014 In the adult brain, self-renewal is essential for the persistence of neural stem cells (NSCs) throughout life, but its regulation is still poorly understood. One NSC can give birth to two NSCs or one NSC and one transient progenitor. A correct balance is
Julien Ferent +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Patched Knockout Mouse Models of Basal Cell Carcinoma
Journal of Skin Cancer, 2012 Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system ...
Frauke Nitzki +4 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
IMAGE SYNTHESIS OF METAL FOAM MICRO-STRUCTURE WITH THE USE OF WANG TILES
Acta Polytechnica CTU Proceedings, 2018 In this paper we present our recent work focused on the analysis of the abilities of Wang Tiles method and Automatic tile design method to synthesize the micro-structure of cellular materials, especially particular type of metal foam.Wang Tiles method ...
Lukáš Zrůbek +5 more
doaj +1 more source