Results 71 to 80 of about 33,084 (302)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
PLoS ONE, 2015 The Hedgehog (Hh) signaling pathway directs a multitude of cellular responses during embryogenesis and adult tissue homeostasis. Stimulation of the pathway results in activation of Hh target genes by the transcription factor Ci/Gli, which binds to ...
Katherine Gurdziel +9 more
doaj +1 more source
Classification of Sleep Apnea Severity by Electrocardiogram Monitoring Using a Novel Wearable Device
Sensors, 2020 Sleep apnea (SA) is a prevalent disorder diagnosed by polysomnography (PSG) based on the number of apnea−hypopnea events per hour of sleep (apnea−hypopnea index, AHI).
Florent Baty +8 more
doaj +1 more source
Patched 1 conditional null allele in mice
, 2003 The patched gene (Ptc) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues.
Kay, Graham F. +8 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
, 1963 Photograph used for a story in the Oklahoma Times newspaper. Caption: "Patched Holes in Main mark spots where circus animals, tents, and other equipment were staked out.
Traverse, Austin
core
Hedgehog Signalling: Pulling Apart Patched and Smoothened
, 2002 Two integral membrane proteins, Patched and Smoothened, were for a long time thought to comprise a preformed receptor complex for secreted Hedgehog signalling proteins.
Stark, David R
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Patched Knockout Mouse Models of Basal Cell Carcinoma
Journal of Skin Cancer, 2012 Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system ...
Frauke Nitzki +4 more
doaj +1 more source