Results 101 to 110 of about 199,906 (316)

On the topology of the inverse limit of a branched covering over a Riemann surface [PDF]

, 2013
We introduce the Plaque Topology on the inverse limit of a branched covering self-map of a Riemann surface of a finite degree greater than one. We present the notions of regular and irregular points in the setting of this Plaque Inverse Limit and study ...
Cabrera, Carlos, Cherif, Chokri, Goldstein, Avraham   +2 more
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling

Stem Cell Reports, 2015
Symmetric and asymmetric divisions are important for self-renewal and differentiation of stem cells during neurogenesis. Although cerebellar granule neurogenesis is controlled by sonic hedgehog (SHH) signaling, whether and how this process is mediated by
Rong Yang, Minglei Wang, Jia Wang, Xingxu Huang, Ru Yang, Wei-Qiang Gao   +5 more
doaj   +1 more source

Impact assessment for vulnerabilities in open-source software libraries

, 2015
Software applications integrate more and more open-source software (OSS) to benefit from code reuse. As a drawback, each vulnerability discovered in bundled OSS potentially affects the application.
Plate, Henrik, Ponta, Serena Elisa, Sabetta, Antonino   +2 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Overlapped conic simulation of three-body trajectories [PDF]

, 1970
Trajectory computation technique for three-body motion is based on analytical derivation and empirical validation of pseudostate theory. Application of technique yields ''overlapped conic'' trajectories with error magnitudes only 20 percent as great as ...
Wilson, S. W., Jr.
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Design of Flyby Trajectories with Powered Gravity and Aerogravity Assist Maneuvers

Aerospace
In this paper, we investigate flyby trajectories combining powered gravity assist (PGA) with aerogravity assist (AGA) in the planar elliptic restricted three-body problem (PERTBP). The patched flyby trajectory is divided into three portions: the PGA, AGA
Wanze Yu, Yi Qi
doaj   +1 more source

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

eLife, 2014
Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development.
Shen Yue, Liu-Ya Tang, Ying Tang, Yi Tang, Qiu-Hong Shen, Jie Ding, Yan Chen, Zengdi Zhang, Ting-Ting Yu, Ying E Zhang, Steven Y Cheng   +10 more
doaj   +1 more source