Results 151 to 160 of about 794,896 (338)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Intellectual Property and Marketing [PDF]
Patent protection spurs innovation by raising the rewards for research, but it usually results in less desirable allocations after the innovation has been discovered. In effect, patents reward inventors with inefficient monopoly power.
Darius Lakdawalla +2 more
core
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Research on technology prospect risk of high-tech projects based on patent analysis. [PDF]
PLoS One, 2020 Zhang L, Liu Z.
europepmc +1 more source
Per-Unit Royalty vs Fixed Fee: The Case of Weak Patents [PDF]
This paper explores a licensor's choice between charging a per-unit royalty or a fixed fee when her innovation is covered by a weak patent, i.e. a patent that is likely to be invali- dated by a court if challenged. Using a general model where the nature
David Encaoua +2 more
core
A new metric for patent retrieval evaluation [PDF]
, 2010 Patent retrieval is generally considered to be a recall-oriented information retrieval task that is growing in importance. Despite this fact, precision based scores such as mean average precision (MAP) remain the primary evaluation measures for patent ...
Jones, Gareth J.F., Magdy, Walid
core
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Analysis of the Status of Iranian Patents in Quadruplet Patent Offices
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2010 The present paper aims to investigate the status of inventions which have been internationally patented with association of Iranian inventors. This research studies the patents of Iranian inventors in quadruplet patent offices during 1990 – 2007. Based upon our findings, 365 Iranian inventors have collaborated in 218 patents and contribution of each of
Mohammad Alaee Arani, Nader Naghshineh
openaire +1 more source