Results 151 to 160 of about 26,374,183 (352)
The Innovative Potential of Key Mentha Species: An Assessment Based on Patent Analysis
Biology and Life Sciences ForumMorocco’s rich biodiversity includes various aromatic and medicinal plants utilized for culinary and medicinal purposes. The genus Mentha, belonging to the Lamiaceae family, is notable for its widespread use in Moroccan culture.
Reda El Boukhari, Ahmed Fatimi
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Technology Mobility and Job Mobility A comparative analysis between patent and survey data [PDF]
In recent years, increasing attention and resources have been devoted to the analysis of workers’ mobility and the collection of new and extensive datasets in order to monitor and appraise this phenomenon.
Camilla Lenzi
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Environmental Research LettersAs the global energy sector transitions towards a cleaner and more sustainable future, observational evidence suggests that many new energy technologies share a close relationship with well-established technologies.
Yiwen Wang, Erin Baker, Anna Goldstein
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Venture Capitalists and Patent Applications of Start-up Firms [PDF]
In this thesis, the effects of ownership structure on the patent applications of start-up firms are examined, focusing particularly on the role of VC. A unique dataset of Japanese start-up firms is used in the analysis, controlling for firm and industry ...
Zhang, Jian Xiong
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Exploring the nanobody patent landscape: a focus on BCMA sequences and structural analysis
mAbsNanobodies (Nbs) are antigen-binding fragments derived from unique heavy-chain-only antibodies. In recent years, the development of Nbs has progressed rapidly due to their therapeutic potential.
Jiaqi Xu +4 more
doaj +1 more source