Results 51 to 60 of about 1,552,229 (290)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Examining the Patent Landscape of E-Fuel Technology
Energies, 2023 Although the end of combustion engine vehicles seems inevitable under a new climate target for 2030, a complete ban on the combustion engine would be counterproductive.
Chie Hoon Song
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Recensione III World Patent Information
, 2015 Recensione III World Patent Information: The International Journal for Industrial Property Documentation, Information, Classification and ...
THOMA, Grid
core +1 more source
Prospects for the Transfer of Intelligent Solutions for a Smart City
Цифровая трансформацияAn analysis of intelligent solutions for all types of V2X technologies communications was carried out the through patent search and development of the patent landscape.
K. S. Astankov +2 more
doaj +1 more source
Information, 2021 Prior studies have extensively discussed firms’ propensity of licensing under different levels of competition. This study clarifies the differences between potential technology competition (PTC) and actual licensing competition (ALC).
Ming Li +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Technology Trends Analysis Using Patent Landscaping [PDF]
Экономика региона, 2017 The article is devoted to the analysis and the choice of the priorities in technology development and, particularly, to the use of patent landscaping as a tool for the study of technology trends.
Sergey Vsevolodovich Kortov +3 more
doaj +1 more source
Synthetic Biology Patent Datasets
, 2022 Providing access to patent datasets for the article Synthetic Biology: Mapping the Patent Landscape.
PAUL OLDHAM
core +1 more source