Results 111 to 120 of about 2,744,703 (304)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
WHAT KIND OF INTELLECTUAL PROPFRTY REGIME IS MORE FAVORABLE TO INNOVATION: WITH OR WITHOUT A PATENT?
Journal of Smart Economic Growth, 2018 Theoretically, the introduction of a patent system serves two purposes: to encourage firms to produce new knowledge and to disseminate information. However, economic practice has highlighted the dilemma between protection and diffusion.
Mohamed Mabrouki
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Recensione III World Patent Information
, 2015 Recensione III World Patent Information: The International Journal for Industrial Property Documentation, Information, Classification and ...
THOMA, Grid
core +1 more source
Patent Protection, Takeovers, and Startup Innovation: A Dynamic Approach [PDF]
The impact of IP protection on the innovation incentives of startup firms is examined in a dynamic model where an incumbent faces a sequence of potential startups and the incumbent's chance of winning an infringement lawsuit increases with the size of ...
In-Uck Park, Andreas Panagopoulos
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Legal protection of plant biotechnological inventions
Agricultural and Food Science, 1989 Within biotechnology, plant production is regarded as one of the most promising adaptations. New plant breeding methods are considered to better fulfil the requirements set on patentability than the traditional breeding methods.
P. T. Vanhala, T. Pehu, H. G. Gyllenberg
doaj
Medicine in Drug DiscoveryBackground: China has recently introduced patent term buchang (PTB) for new drugs. This study presents a systematic profile for China’s PTB, European SPC, and the U.S. PTE for new drug protection.
Hai-Long Zhang, Yongxia Li
doaj +1 more source
Endogenous R&D and Intellectual Property Laws in Developed and Emerging Economies [PDF]
The incentive of providing protection of intellectual property has been analyzed, both for an emerging economy as well as for a developed economy. The optimal patent length and the optimal patent breadth within a country are found to be positively ...
Bagchi, Aniruddha, Roy, Abhra
core
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source