Results 101 to 110 of about 2,744,703 (304)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
To the 50th Anniversary of the European Patent Convention (1973–2023)
Московский журнал международного праваINTRODUCTION. This paper reflects historical overview of long-standing emergence of mechanisms of judicial protections of patent rights conferred by European patens which begun even in 1950-s and ended with start of operations of the Unified Patent Court
R. A. Kasyanov, I. M. Yazberdiev
doaj +1 more source
Competition, Imitation, and R&D Productivity in a Growth Model with Sector-Specific Patent Protection [PDF]
Recent empirical studies suggest a need for a flexible patent regime responding to industry characteristics. In practice, sector-specific modifications of patent strength already exist but lack theoretical foundation.
Malte Mosel
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
What is the Impact of Software Patent Shifts?: Evidence from Lotus v. Borland [PDF]
Economists have debated the extent to which strengthening patent protection spurs or detracts from technological innovation. In this paper, we examine the reduction of software copyright protection in the Lotus v. Borland decision.
Josh Lerner, Feng Zhu
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
ETHICAL BOUNDARIES OF GENETIC ENGINEERING PATENTS IN INDONESIA AND MALAYSIA
Masalah-Masalah HukumGenetic engineering increasingly pushes the boundaries of science, technology, and ethics by raising difficult questions about the acceptable limits of human intervention in living organisms.
Hari Sutra Disemadi +4 more
doaj +1 more source
Patent Systems for Encouraging Innovation: Lessons from Economic Analysis [PDF]
Economic theory views patents as policy instruments aimed at fostering innovation and diffusion. Three major implications are drawn regarding current policy debates.
David Encaoua +2 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Intellectual Property Rights Protection and Imitation - An empirical examination of Japanese FDI in China - [PDF]
By using the data obtained from a questionnaire survey to the Japanese firms in China this paper empirically examines the effects of the IPRs protection against local illegal imitation. No evidence has been found in the test that the patent and trademark
Kegang You, Seiichi Katayama
core