Results 81 to 90 of about 2,744,703 (304)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The Advantages of the Washington Treaty on Patent Cooperation and Its Impact on Economic Development in Contracting States

مجلة القانون، المجتمع والسلطة
As a result of the Paris Convention for the Protection of Industrial Property's inability to cover the procedural aspects of the patent system, international efforts shifted toward proposing a new international framework for inventions, embodied in the ...
Wafa Shaalal, Farhat Hamou
doaj   +1 more source

A Welfare Analysis of Global Patent Protection in a Model with Endogenous Innovation and Foreign Direct Investment [PDF]

This paper constructs a North-South quality-ladder model in which foreign direct investment (FDI) is determined by the endogenous location choice of firms, and examines analytically how strengthening patent protection in the South affects welfare in the ...
Tatsuro Iwaisako, Hitoshi Tanaka, Koichi Futagami   +2 more
core  

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

PROTECTION OF PATENT RIGHTS

, 2018
The difference in the legal system for protecting the scope of patents in various countries,not only importing new investments but also determining the processtechnology transfer of a country. Extensive protection causestechnology transfer is not easy despite lack of protectionbecause the patent owner suffered a loss.
openaire   +4 more sources

Biotechnology and Intellectual Property: The Limits of Animal Patentability in the European Union

Review of European and Comparative Law
The study considers the possibility of patenting animal breeds as objects of intellectual property, taking into account the legislation and law enforcement practices of the European Union.
Mariia Golubei, Liliia Pankova
doaj   +1 more source

Patent protection, imitation and the mode of technology transfer. [PDF]

This paper analyzes a model in which a fir endowed with a new technology can choose between exports, licensing and direct investment as entry modes in a foreign market. I endogenize the vintage of the transferred technology and allow for imitation by the
Fosfuri, Andrea
core  

Parallel imports, drug innovation and international patent protection: a policy game [PDF]

, 2011
We consider a policy game between a high-income country hosting a drug innovator and a low-income country hosting a drug imitator. The low-income country chooses whether to enforce an International Patent Regime (strict IPR) or not (weak IPR), and the ...
Garcia-Alonso, Maria D C, Rajat Acharyya, María D.C. García-Alonso, Acharyya, Rajat   +3 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source