Results 41 to 50 of about 49,360 (161)

Nanostructured and Functionalized Calcium Hydroxyapatite Enhances Collagen Production by Human Dermal Fibroblasts Compared With Microstructured Counterparts In Vitro

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 8, August 2026.
Nanostructured, lactose‐functionalized calcium hydroxyapatite (nanoCaHA) was produced by nanospray drying, yielding submicron, amorphous, carbonated particles with improved physicochemical properties. NanoCaHA was biocompatible and outperformed microstructured CaHA in stimulating collagen‐related gene expression and total collagen production in human ...
Elizabeth Cristina Iseke Bispo, Stefhani Martins de Barcelos, Jonad Logan A. Contarato, Atailson Oliveira da Silva, Rafael Vieira Rocho, Ana Clara Nogueira Brathwaite, Venâncio Alves Amaral, Paula Martins de Oliveira, Maria Victória Souto‐Silva, Graziella Anselmo Joanitti, Marcilio Cunha‐Filho, Guilherme Martins Gelfuso, Juliana Lott de Carvalho, Felipe Saldanha‐Araújo, Taís Gratieri   +14 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Propiedad intelectual y patentes sobre usos medicinales en conocimientos tradicionales

Investigación Agraria, 2018
En este trabajo se analiza el conocimiento tradicional sobre las supuestas propiedades medicinales de plantas y sus usos, como parte de los bienes comunes, que tiene la protección del derecho interno y del derecho internacional. Se consideran los usos de
Ramón Fogel
doaj   +1 more source

Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez, Lídia Vaqué‐Alcázar, Susana Clos, Bessy Benejam, Maria Carmona‐Iragui, Lucía Maure‐Blesa, Laura Videla, Nuole Zhu, Miren Altuna, Javier Arranz, Isabel Barroeta, Íñigo Rodríguez‐Baz, Alexandre Bejanin, Ana Bueno, Susana Fernandez, Laura del Hoyo Soriano, Lucia Pertierra, Daniel Alcolea, Bruce Miller, Lea T. Grinberg, Joaquin Ruiz, Christos Panagiotis Lisgaras, Hau‐Tieng Wu, Alberto Lleó, Ricardo S. Osorio, Esther M. Blessing, Juan Fortea   +26 more
wiley   +1 more source

Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome (DS)–associated AD (DSAD).
Alejandra O. Morcillo‐Nieto, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, José Enrique Arriola‐Infante, Lídia Vaqué‐Alcázar, Mateus Rozalem‐Aranha, José Allende Parra, Zili Zhao, Javier Arranz, Íñigo Rodríguez‐Baz, Lucia Maure‐Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Miguel Santos‐Santos, Oriol Dols‐Icardo, Ignacio Illán‐Gala, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +27 more
wiley   +1 more source

Reflexiones sobre las nuevas directivas de patentabilidad para invenciones farmacéuticas

Revista Iberoamericana de la Propiedad Intelectual, 2013
Lo que se pretende es realizar un ejercicio de reflexión sobre la aplicación del sistema de patentes al ámbito de los medicamentos farmacéuticos tomando como tópico disparador la Resolución Conjunta citada.
Pablo Tomás Lamas
doaj  

Mapping the Technological and Pharmacological Landscape of Casearia sylvestris: An Evidence‐Based Prospection for Wound Healing and Pain Management

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Technological prospection of Casearia sylvestris for wound healing reveals limited patent and scientific production, concentrated on topical formulations and associated analgesic and anti‐inflammatory properties. Key innovation gaps persist, including insufficient chemical and biological standardization, lack of clinical evidence, and restricted ...
Luiza Gonçalves Soutier, Yasmim Parisotto de Souza Silva, Carla Suelen Gurski, Jaqueline Carneiro, Jéssica Brandão Reolon, Roberto Pontarolo, Marcel Henrique Marcondes Sari, Gabriel Blum Vestena, Weber Cláudio Francisco Nunes da Silva, Juliana Sartori Bonini, Luana Mota Ferreira   +10 more
wiley   +1 more source

La financiarización de las grandes empresas farmacéuticas

Revista Internacional de Sociología, 2020
En este artículo, empleamos un marco Vebleniano para analizar tres dimensiones de la financiarización corporativa: la expansión del balance, la creciente importancia de los activos intangibles y los crecientes niveles de pagos financieros.
Tobias J. Klinge, Rodrigo Fernandez, Manuel B. Aalbers   +2 more
doaj   +1 more source

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez, Camila Leiva‐Castro, Ana M. Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López‐Enríquez, Francisca Palomares   +6 more
wiley   +1 more source

A Comprehensive Evaluation of Patient Satisfaction and Clinical Outcomes in Poly‐L‐Lactic Acid Treatments—A Randomized, Interventional, and Comparative Clinical Study

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Poly‐L‐lactic acid (PLLA) is widely used in aesthetic medicine due to its bio‐stimulatory properties. However, limited research has compared different PLLA formulations. Aim To evaluate the impact of PLLA formulation and injection depth (subcutaneous vs. supraperiosteal) using objective and subjective assessments.
Victor R. M. Munoz‐Lora, Danielle Dias, Fernanda Bezerra, Ana C. N. Carnevali, Rud Varela, Andrea D. Tedesco, Pietra Roschel, Gabriela Giro, Patrícia Pauletto, Victor Rogerio, Marcelo Germani   +10 more
wiley   +1 more source