Results 31 to 40 of about 49,360 (161)

CSF fibrinogen predicts longitudinal Tau accumulation in cognitively unimpaired older adults

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD). Fibrinogen represents a sensitive marker of BBB leakage, but whether it modifies longitudinal tau progression in cognitively unimpaired (CU) individuals remains unknown.
Christos Panagiotis Lisgaras, Tovia Jacobs, Luisa Figueredo, Elizabeth Pirraglia, Caleb H Radtke, Jonah N Keller, Nikolaos Karvelas, Jennifer Bernal, Joaquin Ruiz, Henrik Zetterberg, Lidia Glodzik, Mony J de Leon, Laura Beth McIntire, Allal Boutajangout, Thomas Wisniewski, Jaime Ramos‐Cejudo, Daniel Alcolea, Sandra Giménez, Juan Fortea, Katerina Akassoglou, Fanny M Elahi, Ricardo S Osorio   +21 more
wiley   +1 more source

La mercantilización del derecho a la salud: patentes farmacéuticas

Deusto Journal of Human Rights, 2017
In spite of the great developments in medicine in the 20th century, the healthcare and the quality of life of millions of people living in developing countries are still under the acceptable limits.
Lourdes Collado Rodríguez
doaj   +1 more source

Criteria for Control and Remission of Respiratory Allergic Disease With Allergen Immunotherapy: A Delphi Consensus

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
Expert consensus using a Delphi methodology proposed definitions of control and remission for allergic rhinitis, conjunctivitis and asthma in the context of allergen immunotherapy. These consensus‐based criteria integrate symptoms, medication use, patient‐reported outcomes and objective measures to support a more structured assessment of treatment ...
Eloína González‐Mancebo, Juan María Beitia Mazuecos, Ana I Tabar Purroy, Mar Gandolfo‐Cano, Adriana Izquierdo‐Domínguez, María José Castillo Marchuet, Cristina Cuevas Bravo, Leticia Domínguez Cereijo, Alicia Enríquez‐Matas, Ignacio Esteban Gorgojo, Adrián Germán Sánchez, Alba Juárez Guerrero   +11 more
wiley   +1 more source

Análise do processo administrativo de concessão de patentes farmacêuticas: há necessidade de prazo mínimo de vigência efetiva?

, 2022
Esta pesquisa tem como objetivo analisar o processo administrativo de concessão de patentes farmacêuticas. Para tanto, é abordado o contexto legislativo brasileiro que acabou gerando uma ineficiência do INPI em realizar o exame célere desses pedidos de
Brito, Ana Luiza
core  

Vobramitamab duocarmazine, an anti–B7‐H3 antibody–drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion

Cancer, Volume 132, Issue 15, 1 August 2026.
Abstract Background Vobramitamab duocarmazine is an investigational antibody–drug conjugate (ADC) targeting B7 homolog 3 (B7‐H3) with a cytotoxic duocarmycin‐based DNA‐alkylating payload. This study evaluated its safety and antitumor activity in advanced solid tumors.
Eugene Shenderov, Manish R. Sharma, Elena Garralda, John Powderly, Iwona Ługowska, Alexander Spira, Marc Cucurull Salamero, Sekwon Jang, Rasha Cosman, John Shen, Wen Xu, Piotr J. Wysocki, Rodryg Ramlau, Emmanuel S. Antonarakis, Andrew J. Weickhardt, Jakub Żołnierek, Emiliano Calvo, Enxu Zhao, Chet Bohac, Ashley Ward, Girish Mallesara   +20 more
wiley   +1 more source

A inovação nas incubadoras tecnológicas :: uma análise sob a ótica das patentes / [PDF]

, 1999
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Sócio-Econômico.Resultado de uma pesquisa realizada com 73 empresas residentes em 9 incubadoras tecnológicas no Brasil, a proposta deste estudo é analisar as inovações desenvolvidas ...
Prado, Evandro José da Silva
core  

Policy Networks and Policy Entrepreneurship in the EU: Explaining Structural Policy Change in Pharmaceutical Innovation Incentives and Health Technology Assessment

European Policy Analysis, Volume 12, Issue 4, Fall 2026.
ABSTRACT Policy process research has excelled in explaining structural policy change within national settings, but extensions and applications to the EU level have long proven challenging for scholars. Given that the EU is currently experiencing its longest period of Treaty stability since the 1980s—having evolved into a sui generis political system ...
Vassilis Karokis‐Mavrikos
wiley   +1 more source

PATENTES FARMACÊUTICAS E O ACESSO A VACINAS EM PAÍSES DO SUL GLOBAL: UM ENFOQUE BRASILEIRO [PDF]

Motivado pelo contencioso de patentes farmacêuticas observado durante a pandemia de Covid-19, o presente estudo tem como objetivo analisar a disputa norte-sul neste contencioso durante o período pandêmico.
Barros, Manoela, Russo, Eduardo
core   +1 more source

Policy Games Large and Small: Explaining the Inclusion of Transferable Data Exclusivity Vouchers in the EU's Pharmaceutical Revision Through Actor‐Centered Institutionalism

European Policy Analysis, Volume 12, Issue 4, Fall 2026.
ABSTRACT In the 2025 revision of the EU's pharmaceutical legislation, transferable data exclusivity vouchers were included as a novel incentive for antimicrobial development. In light of considerable controversy around these vouchers throughout the legislative process, this is a surprising outcome.
Paula Dornbusch
wiley   +1 more source

OS MEDICAMENTOS E AS PATENTES PIPELINE: CONVERGÊNCIAS E DISTANCIAMENTOS ENTRE A ORDEM JURÍDICA CONSTITUIÇÃO BRASILEIRA E AS PREVISÕES ESTRANGEIRAS

Revista Direitos Humanos e Democracia, 2016
O presente trabalho visa aquilatar uma análise geral sobre o tema “patente” em especial a pipiline, bem como suas formas de concessão e os principais acontecimentos relacionados à evolução do tema em na ordem jurídica brasileira e no cenário estrangeiro.
Dirceu Pereira Siqueira, Bruna Fernandes Alves   +1 more
doaj   +1 more source