Results 21 to 30 of about 176 (123)

Sharing the Burden: The Impacts of Pharmacy Sector Reforms on the Labor Market for Pharmacists in Portugal

Industrial Relations: A Journal of Economy and Society, EarlyView.
ABSTRACT During the 2010 crisis, the Portuguese government enacted several reforms to its prescription drug reimbursement system. As a result, value added per pharmacist in pharmacies fell by a third. We use longitudinal records from Quadros de Pessoal (QP), merged with collective bargaining data and firm financial records, to study the impacts of the ...
David Card, Ana Rute Cardoso, Pedro Luis Silva   +2 more
wiley   +1 more source

Criteria for Control and Remission of Respiratory Allergic Disease With Allergen Immunotherapy: A Delphi Consensus

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
Expert consensus using a Delphi methodology proposed definitions of control and remission for allergic rhinitis, conjunctivitis and asthma in the context of allergen immunotherapy. These consensus‐based criteria integrate symptoms, medication use, patient‐reported outcomes and objective measures to support a more structured assessment of treatment ...
Eloína González‐Mancebo, Juan María Beitia Mazuecos, Ana I Tabar Purroy, Mar Gandolfo‐Cano, Adriana Izquierdo‐Domínguez, María José Castillo Marchuet, Cristina Cuevas Bravo, Leticia Domínguez Cereijo, Alicia Enríquez‐Matas, Ignacio Esteban Gorgojo, Adrián Germán Sánchez, Alba Juárez Guerrero   +11 more
wiley   +1 more source

Vobramitamab duocarmazine, an anti–B7‐H3 antibody–drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion

Cancer, Volume 132, Issue 15, 1 August 2026.
Abstract Background Vobramitamab duocarmazine is an investigational antibody–drug conjugate (ADC) targeting B7 homolog 3 (B7‐H3) with a cytotoxic duocarmycin‐based DNA‐alkylating payload. This study evaluated its safety and antitumor activity in advanced solid tumors.
Eugene Shenderov, Manish R. Sharma, Elena Garralda, John Powderly, Iwona Ługowska, Alexander Spira, Marc Cucurull Salamero, Sekwon Jang, Rasha Cosman, John Shen, Wen Xu, Piotr J. Wysocki, Rodryg Ramlau, Emmanuel S. Antonarakis, Andrew J. Weickhardt, Jakub Żołnierek, Emiliano Calvo, Enxu Zhao, Chet Bohac, Ashley Ward, Girish Mallesara   +20 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

La mercantilización del derecho a la salud: patentes farmacéuticas

Deusto Journal of Human Rights, 2017
In spite of the great developments in medicine in the 20th century, the healthcare and the quality of life of millions of people living in developing countries are still under the acceptable limits.
Lourdes Collado Rodríguez
doaj   +1 more source

Characterizing circadian rest–activity rhythm patterns across Alzheimer's disease continuum in Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Sleep and circadian rest–activity rhythm (RAR) disruption may bidirectionally relate to Alzheimer's disease (AD). Down syndrome (DS), the most common genetic cause of AD, presents sleep disorders, yet RAR patterns across the DS‐associated AD continuum remain uncharacterized. METHODS We analyzed 7‐day wrist actigraphy in 140 adults
Sandra Giménez, Lídia Vaqué‐Alcázar, Susana Clos, Bessy Benejam, Maria Carmona‐Iragui, Lucía Maure‐Blesa, Laura Videla, Nuole Zhu, Miren Altuna, Javier Arranz, Isabel Barroeta, Íñigo Rodríguez‐Baz, Alexandre Bejanin, Ana Bueno, Susana Fernandez, Laura del Hoyo Soriano, Lucia Pertierra, Daniel Alcolea, Bruce Miller, Lea T. Grinberg, Joaquin Ruiz, Christos Panagiotis Lisgaras, Hau‐Tieng Wu, Alberto Lleó, Ricardo S. Osorio, Esther M. Blessing, Juan Fortea   +26 more
wiley   +1 more source

Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome (DS)–associated AD (DSAD).
Alejandra O. Morcillo‐Nieto, Maria Franquesa‐Mullerat, Sara E. Zsadanyi, José Enrique Arriola‐Infante, Lídia Vaqué‐Alcázar, Mateus Rozalem‐Aranha, José Allende Parra, Zili Zhao, Javier Arranz, Íñigo Rodríguez‐Baz, Lucia Maure‐Blesa, Laura Videla, Isabel Barroeta, Laura Del Hoyo Soriano, Bessy Benejam, Susana Fernández, Aida Sanjuan Hernandez, Lucia Pertierra, Sandra Giménez, Miguel Santos‐Santos, Oriol Dols‐Icardo, Ignacio Illán‐Gala, Daniel Alcolea, Olivia Belbin, Alberto Lleó, María Carmona‐Iragui, Juan Fortea, Alexandre Bejanin   +27 more
wiley   +1 more source

Mapping the Technological and Pharmacological Landscape of Casearia sylvestris: An Evidence‐Based Prospection for Wound Healing and Pain Management

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Technological prospection of Casearia sylvestris for wound healing reveals limited patent and scientific production, concentrated on topical formulations and associated analgesic and anti‐inflammatory properties. Key innovation gaps persist, including insufficient chemical and biological standardization, lack of clinical evidence, and restricted ...
Luiza Gonçalves Soutier, Yasmim Parisotto de Souza Silva, Carla Suelen Gurski, Jaqueline Carneiro, Jéssica Brandão Reolon, Roberto Pontarolo, Marcel Henrique Marcondes Sari, Gabriel Blum Vestena, Weber Cláudio Francisco Nunes da Silva, Juliana Sartori Bonini, Luana Mota Ferreira   +10 more
wiley   +1 more source

Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions

British Journal of Pharmacology, Volume 183, Issue 9, Page 1993-2008, May 2026.
Abstract Background and Purpose Immune tolerance prevents inflammation and autoimmunity, with dendritic cells (DCs) playing a key role. Reprogramming DCs towards a tolerogenic state represents a promising therapeutic strategy. Sulforaphane (SFN) has known immunomodulatory effects, but its clinical application is limited by poor stability and ...
María Elena Angarita‐Planchez, Camila Leiva‐Castro, Ana M. Múnera‐Rodríguez, Macarena Martínez‐Bailén, Ana T. Carmona, Soledad López‐Enríquez, Francisca Palomares   +6 more
wiley   +1 more source

OS MEDICAMENTOS E AS PATENTES PIPELINE: CONVERGÊNCIAS E DISTANCIAMENTOS ENTRE A ORDEM JURÍDICA CONSTITUIÇÃO BRASILEIRA E AS PREVISÕES ESTRANGEIRAS

Revista Direitos Humanos e Democracia, 2016
O presente trabalho visa aquilatar uma análise geral sobre o tema “patente” em especial a pipiline, bem como suas formas de concessão e os principais acontecimentos relacionados à evolução do tema em na ordem jurídica brasileira e no cenário estrangeiro.
Dirceu Pereira Siqueira, Bruna Fernandes Alves   +1 more
doaj   +1 more source