Results 81 to 90 of about 147,683 (344)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Refining the Measurement of Topic Similarities Through Bibliographic Coupling and LDA

IEEE Access, 2019
Generally, two topics with vastly different terminology probably indicate different implied concepts. However, these topics themselves might share common references (bibliographic coupling), which suggest the underlying joint concept.
Omer Hanif, Zhu Donghua, Wang Xuefeng, M. Saqib Nawaz   +3 more
doaj   +1 more source

Knowledge Integration and Diffusion: Measures and Mapping of Diversity and Coherence

, 2014
I present a framework based on the concepts of diversity and coherence for the analysis of knowledge integration and diffusion. Visualisations that help understand insights gained are also introduced. The key novelty offered by this framework compared to
A Skupin, A Stirling, AL Porter, AL Porter, AL Porter, C Chen, C Ricotta, CR Rao, EJ Hackett, F Havemann, F Moya-Anegón, G Dosi, H Etzkowitz, I Rafols, I Rafols, I Rafols, I Rafols, K Börner, KW Boyack, KW Boyack, KW Boyack, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Leydesdorff, L Nesta, L Nesta, L Waltman, LK Hessels, M Gibbons, M Rosvall, National Academies, P Ahlgren, P Jensen, P Lowe, P Nightingale, R Barré, R Klavans, R Klavans, RA Boschma, S Carley, S Soós, S Soós, TJ Pinch, X Polanco, Y Kajikawa, Y Takeda, YX Liu, YX Liu   +50 more
core   +1 more source

Compulsory Licensing of Patented Pharmaceutical Inventions: Evaluating the Options [PDF]

, 2009
In this Comment, the author traces the relevant legislative history pertaining to compulsory licensing of patented pharmaceuticals from the TRIPS Agreement of 1994 to the 2003 waiver to, and later proposed amendment of, article 31, which enables poor ...
Arezzo, Coco, Danzon, Danzon, Debrulle, Drahos, Drexl, Fox, Hovenkamp, Hovenkamp, Jerome H. Reichman, Love, Lybecker, Maskus, Mercurio, Mercurio, Moran, Outterson, Reichman, Reichman, Reichman, Watal, Yu   +22 more
core   +2 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Watkins\u27 Patent trolls: Predatory litigation and the smothering of innovation (Book Review)

, 2017
A review of Watkins, W. J., Jr. (2013). Patent trolls: Predatory litigation and the smothering of innovation. Oakland, CA: The Independent Institute. 96 pp. $17.95.
Strain, Judson L.
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Mining digital identity insights: patent analysis using NLP

EURASIP Journal on Information Security
The field of digital identity innovation has grown significantly over the last 30 years, with over 6000 technology patents registered worldwide. However, many questions remain about who controls and owns our digital identity and intellectual property and,
Matthew Comb, Andrew Martin
doaj   +1 more source